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Tbio
CLPB
Caseinolytic peptidase B protein homolog

Protein Summary
Description
May function as a regulatory ATPase and be related to secretion/protein trafficking process. This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing resul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294053
  • ENSP00000294053
  • ENSG00000162129
  • ENST00000340729
  • ENSP00000340385
  • ENST00000437826
  • ENSP00000407296
  • ENST00000538039
  • ENSP00000441518

Symbol
  • HSP78
  • SKD3
  • SKD3
  • HSP78
  • MGCA7
  • ANKCLB
  • MEGCANN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
transcription factor binding site profile
0.96
gene perturbation
0.92
protein domain
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 533.16   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 533.16   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (213)
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.999995636
p_ni:  0.000004364
Score:  0.218
Data Source:  BioPlex,STRINGDB
KIAA1191
Tdark
Family:  Enzyme
Novelty:  3.7888034
p_int:  0.999989493
p_ni:  0.000010507
Score:  0.206
Data Source:  BioPlex,STRINGDB
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.999977888
p_ni:  0.000022112
Data Source:  BioPlex
ARFIP1
Tbio
Novelty:  0.20178246
p_int:  0.999459905
p_ni:  0.000540095
Score:  0.198
Data Source:  BioPlex,STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.999422299
p_ni:  0.000577701
Score:  0.359
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.99845513
p_ni:  0.001544869
p_wrong:  1e-9
Data Source:  BioPlex
UCHL3
Tchem
Family:  Enzyme
Novelty:  0.01206871
p_int:  0.996115898
p_ni:  0.003884102
Score:  0.568
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.995587935
p_ni:  0.004412065
Score:  0.636
Data Source:  BioPlex,STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.995110144
p_ni:  0.004889856
Data Source:  BioPlex
GTPBP10
Tbio
Novelty:  0.18563864
p_int:  0.994446785
p_ni:  0.005546535
p_wrong:  0.000006681
Score:  0.236
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
66.3
body height
1
1
1
24.5
electrocardiography
1
1
1
15.8
heart rate response to recovery post exercise
1
1
1
9.9
mathematical ability
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
66.3
body height
1
24.5
electrocardiography
1
15.8
heart rate response to recovery post exercise
1
9.9
mathematical ability
1
1.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ClpB homolog, mitochondrial AAA ATPase chaperonin
VGNC:6758
748346
Macaque
ClpB homolog, mitochondrial AAA ATPase chaperonin
718461
Mouse
MGI:1100517
20480
Rat
RGD:621328
65041
Dog
ClpB homolog, mitochondrial AAA ATPase chaperonin
VGNC:39355
476815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ClpB homolog, mitochondrial AAA ATPase chaperonin
Macaque
ClpB homolog, mitochondrial AAA ATPase chaperonin
Mouse
Rat
Dog
ClpB homolog, mitochondrial AAA ATPase chaperonin
Publication Statistics
PubMed Score 533.16
PubMed score by year
PubTator Score 83.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title