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Tbio
CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

Protein Summary
Description
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302731
  • ENSP00000304704
  • ENSG00000172409
  • ENST00000525602
  • ENSP00000436066
  • ENST00000533682
  • ENSP00000434995

Symbol
  • HEAB
  • HEAB
  • hClp1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.97
molecular function
0.96
interacting protein
0.76
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (276)
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.999704569
p_ni:  0.000295431
Score:  0.99
Data Source:  BioPlex,STRINGDB
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.998276643
p_ni:  0.001723357
Score:  0.251
Data Source:  BioPlex,STRINGDB
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.989355415
p_ni:  0.010644585
Score:  0.988
Data Source:  BioPlex,STRINGDB
AMMECR1
Tbio
Novelty:  0.12679247
p_int:  0.881123286
p_ni:  0.118876714
Score:  0.395
Data Source:  BioPlex,STRINGDB
MBLAC1
Tdark
Family:  Enzyme
Novelty:  0.48250122
p_int:  0.756159944
p_ni:  0.243840056
Score:  0.54
Data Source:  BioPlex,STRINGDB
PCF11
Tbio
Novelty:  0.01882626
Score:  0.997
Data Source:  Reactome,STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.99
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.988
Data Source:  STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.986
Data Source:  STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.1
mathematical ability
1
1
1
81
neuroticism measurement
5
6
3
6
79.3
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
3
3
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.1
mathematical ability
1
81
neuroticism measurement
3
6
79.3
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
3
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2138968
98985
Rat
RGD:1307679
311166
Dog
cleavage and polyadenylation factor I subunit 1
VGNC:39354
610161
Horse
cleavage and polyadenylation factor I subunit 1
VGNC:16628
100066955
Cow
cleavage and polyadenylation factor I subunit 1
VGNC:27457
506507
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cleavage and polyadenylation factor I subunit 1
Horse
cleavage and polyadenylation factor I subunit 1
Cow
cleavage and polyadenylation factor I subunit 1
Publication Statistics
PubMed Score 23.86
PubMed score by year
PubTator Score 38.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title