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Tbio
CLNS1A
Methylosome subunit pICln

Protein Summary
Description
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume cont ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525428
  • ENSP00000433919
  • ENSG00000074201
  • ENST00000528364
  • ENSP00000434311

Symbol
  • CLCI
  • ICLN
  • CLCI
  • ICln
  • CLNS1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
drug perturbation
0.99
interacting protein
0.88
kinase perturbation
0.88
disease perturbation
0.87


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999993427
p_ni:  0.000006573
Score:  0.852
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999988529
p_ni:  0.000011471
Score:  0.665
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999988378
p_ni:  0.000011622
Score:  0.992
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999961963
p_ni:  0.000038037
Score:  0.385
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999907355
p_ni:  0.000092645
Score:  0.968
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999838358
p_ni:  0.000161642
Score:  0.971
Data Source:  BioPlex,STRINGDB
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.999832166
p_ni:  0.000167834
Score:  0.186
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999810365
p_ni:  0.000189635
Score:  0.773
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999504242
p_ni:  0.000495758
Data Source:  BioPlex
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.999227419
p_ni:  0.000772581
Score:  0.266
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
71.6
diastolic blood pressure
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
71.6
diastolic blood pressure
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chloride nucleotide-sensitive channel 1A
699904
Mouse
MGI:109638
12729
Rat
RGD:61884
65160
Dog
chloride nucleotide-sensitive channel 1A
403971
Horse
chloride nucleotide-sensitive channel 1A
VGNC:16626
100063117
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chloride nucleotide-sensitive channel 1A
Mouse
Rat
Dog
chloride nucleotide-sensitive channel 1A
Horse
chloride nucleotide-sensitive channel 1A
Publication Statistics
PubMed Score 56.71
PubMed score by year
PubTator Score 31.20
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title