Tbio CLMN Calmin

Protein Summary

Uniprot Accession IDs

• Q96JQ2
• B2RAR7
• Q9H713
• Q9HA23
• Q9HA57
• Q9UFP4
• Q9ULN2

Gene Name

• CLMN

Ensembl ID

• ENST00000298912
• ENSP00000298912
• ENSG00000165959

Symbol

• KIAA1188

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
gene perturbation	0.82
cell type or tissue	0.8
trait	0.75
histone modification site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.18   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.18   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

• See Interactions on String-DB

PPL

Tbio

Novelty:  0.00684645

p_int:  0.999999784

p_ni:  1.85e-7

p_wrong:  3.1e-8

Data Source:  BioPlex

UBL4B

Tdark

Novelty:  0.56877836

p_int:  0.999950574

p_ni:  0.000047276

p_wrong:  0.00000215

Data Source:  BioPlex

ADCY9

Tbio

Family:  Enzyme

Novelty:  0.00744116

p_int:  0.999757303

p_ni:  0.000242384

p_wrong:  3.12e-7

Data Source:  BioPlex

CCSMST1

Tdark

Novelty:  0.60610244

p_int:  0.999480869

p_ni:  5.57e-7

p_wrong:  0.000518574

Data Source:  BioPlex

TCTEX1D2

Tbio

Novelty:  0.15075459

p_int:  0.997577546

p_ni:  1.77e-7

p_wrong:  0.002422277

Score:  0.369

Data Source:  BioPlex,STRINGDB

TAOK2

Tchem

Family:  Kinase

Novelty:  0.0232708

p_int:  0.996764891

p_ni:  0.003206012

p_wrong:  0.000029097

Data Source:  BioPlex

UQCC1

Tbio

Family:  Enzyme

Novelty:  0.03937066

p_int:  0.966911126

p_ni:  0.033088874

Data Source:  BioPlex

AP2M1

Tbio

Novelty:  0.00769368

p_int:  0.857105918

p_ni:  0.142894082

Data Source:  BioPlex

SUN2

Tbio

Novelty:  0.01387591

p_int:  0.825991541

p_ni:  0.173993473

p_wrong:  0.000014986

Score:  0.171

Data Source:  BioPlex,STRINGDB

RAB21

Tbio

Family:  Enzyme

Novelty:  0.03221825

p_int:  0.82020123

p_ni:  0.179730691

p_wrong:  0.000068078

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

WikiPathways (4)

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Vitamin D Receptor Pathway	903 targets	WP2877_r105854
WikiPathways	Vitamin D Receptor Pathway	903 targets	WP2877_r105854
WikiPathways	Vitamin D Receptor Pathway	903 targets	WP2877_r105854
WikiPathways	Ras Signaling	2526 targets	WP4223_r105681

Name	Explore in Pharos	Explore in Source
Vitamin D Receptor Pathway	903 targets	WP2877_r105854
Vitamin D Receptor Pathway	903 targets	WP2877_r105854
Vitamin D Receptor Pathway	903 targets	WP2877_r105854
Ras Signaling	2526 targets	WP4223_r105681

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (4)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	3	4		86
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		42.3
Alzheimer's disease	EFO_0000249	1	1	1		21.5
gut microbiome measurement	EFO_0007874	1	1	0	5.5	15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	4		86
sex hormone-binding globulin measurement	EFO_0004696	2		42.3
Alzheimer's disease	EFO_0000249	1		21.5
gut microbiome measurement	EFO_0007874	0	5.5	15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
gut microbiome measurement
heel bone mineral density
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	calmin	VGNC:13032	742863
Macaque	calmin		709910
Mouse	calmin	MGI:2136957	94040
Rat	calmin	RGD:1306741	299285
Dog	calmin	VGNC:39350	480427

Species	Name	OMA	EggNOG	Inparanoid
Chimp	calmin
Macaque	calmin
Mouse	calmin
Rat	calmin
Dog	calmin

Publication Statistics

PubMed Score 15.18

PubMed score by year

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PubTator Score 10.76

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title