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Tchem
CLK2
Dual specificity protein kinase CLK2

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-ri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361168
  • ENSP00000354856
  • ENSG00000176444
  • ENST00000368361
  • ENSP00000357345
  • ENST00000572269
  • ENSP00000459461
  • ENSG00000261893
  • ENST00000574445
  • ENSP00000460443
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
disease perturbation
0.95
molecular function
0.94
kinase perturbation
0.93
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (97)
RSRP1
Tdark
Novelty:  0.74980508
p_int:  0.999998714
p_ni:  0.000001126
p_wrong:  1.6e-7
Score:  0.575
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999991456
p_ni:  0.000008544
Score:  0.589
Data Source:  BioPlex,STRINGDB
NKTR
Tbio
Novelty:  0.01287691
p_int:  0.999991076
p_ni:  0.000008924
Score:  0.535
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.999989708
p_ni:  0.000010292
Score:  0.648
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.999982412
p_ni:  0.000017588
Score:  0.698
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.999968671
p_ni:  0.000031329
Score:  0.537
Data Source:  BioPlex,STRINGDB
CLK1
Tchem
Family:  Kinase
Novelty:  0.00812732
p_int:  0.999950438
p_ni:  0.000048724
p_wrong:  8.38e-7
Score:  0.72
Data Source:  BioPlex,STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.999924195
p_ni:  0.000075805
Score:  0.501
Data Source:  BioPlex,STRINGDB
PPHLN1
Tbio
Novelty:  0.21311177
p_int:  0.999811657
p_ni:  0.000188343
Score:  0.439
Data Source:  BioPlex,STRINGDB
RBBP6
Tbio
Family:  Enzyme
Novelty:  0.03147368
p_int:  0.999754238
p_ni:  0.000245762
Score:  0.797
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (82)
Items per page:
1 – 5 of 82
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
5
9
98.3
urate measurement
6
5
9
98.3
serum urea measurement
2
3
3
95.4
serum urea measurement
2
3
3
95.4
reticulocyte measurement
3
2
4
93.8
Items per page:
1 – 5 of 82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
98.3
urate measurement
9
98.3
serum urea measurement
3
95.4
serum urea measurement
3
95.4
reticulocyte measurement
4
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1098669
12748
Dog
CDC like kinase 2
VGNC:39347
490427
Horse
CDC like kinase 2
VGNC:16620
100063546
Cow
CDC like kinase 2
VGNC:27449
512737
Pig
CDC like kinase 2
100155149
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
CDC like kinase 2
Horse
CDC like kinase 2
Cow
CDC like kinase 2
Pig
CDC like kinase 2
Publication Statistics
PubMed Score 8.32
PubMed score by year
PubTator Score 20.36
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title