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Tbio
CLIP1
CAP-Gly domain-containing linker protein 1

Protein Summary
Description
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302528
  • ENSP00000303585
  • ENSG00000130779
  • ENST00000358808
  • ENSP00000351665
  • ENST00000537178
  • ENSP00000445531
  • ENST00000540338
  • ENSP00000439093
  • ENST00000620786
  • ENSP00000479322

Symbol
  • CYLN1
  • RSN
  • RSN
  • CLIP
  • CYLN1
  • CLIP170
  • CLIP-170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.97
drug perturbation
0.96
cellular component
0.92
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.63   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.63   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (209)
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.999999996
p_ni:  4e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999999574
p_ni:  3.99e-7
p_wrong:  2.7e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999994839
p_ni:  0.000005161
Data Source:  BioPlex
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.999984884
p_ni:  0.000015076
p_wrong:  4e-8
Score:  0.695
Data Source:  BioPlex,STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
p_int:  0.99994685
p_ni:  0.000046731
p_wrong:  0.000006419
Score:  0.225
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999735778
p_ni:  0.000264208
p_wrong:  1.5e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.998
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.993
Data Source:  Reactome,STRINGDB
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
8
8
95.6
waist-hip ratio
1
8
8
95.3
body mass index
5
3
6
92.2
BMI-adjusted hip circumference
2
9
9
90.7
waist circumference
1
4
4
88.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
95.6
waist-hip ratio
8
95.3
body mass index
6
92.2
BMI-adjusted hip circumference
9
90.7
waist circumference
4
88.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CAP-Gly domain containing linker protein 1
VGNC:8382
467147
Macaque
CAP-Gly domain containing linker protein 1
702137
Mouse
MGI:1928401
56430
Rat
RGD:67404
65201
Dog
CAP-Gly domain containing linker protein 1
VGNC:39343
477461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CAP-Gly domain containing linker protein 1
Macaque
CAP-Gly domain containing linker protein 1
Mouse
Rat
Dog
CAP-Gly domain containing linker protein 1
Publication Statistics
PubMed Score 253.63
PubMed score by year
PubTator Score 522.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title