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Tbio
CLINT1
Clathrin interactor 1

Protein Summary
Description
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000411809
  • ENSP00000388340
  • ENSG00000113282
  • ENST00000523094
  • ENSP00000429345
  • ENST00000523908
  • ENSP00000429824
  • ENST00000530742
  • ENSP00000433419

Symbol
  • ENTH
  • EPN4
  • EPNR
  • KIAA0171
  • ENTH
  • EPN4
  • EPNR
  • CLINT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
ligand (protein) perturbation
0.83
interacting protein
0.8
disease perturbation
0.79
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.999994882
p_ni:  0.000005118
Score:  0.517
Data Source:  BioPlex,STRINGDB
BMP2K
Tchem
Family:  Kinase
Novelty:  0.10145601
p_int:  0.999992429
p_ni:  0.000007571
Score:  0.813
Data Source:  BioPlex,STRINGDB
PIK3C2A
Tchem
Family:  Kinase
Novelty:  0.0002219
p_int:  0.999963174
p_ni:  0.000036826
Score:  0.986
Data Source:  BioPlex,STRINGDB
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.999929334
p_ni:  0.000070481
p_wrong:  1.85e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
STON2
Tbio
Novelty:  0.02098671
p_int:  0.999901492
p_ni:  0.000098369
p_wrong:  1.39e-7
Score:  0.718
Data Source:  BioPlex,STRINGDB
REPS1
Tbio
Novelty:  0.08952347
p_int:  0.999603571
p_ni:  0.000396429
Score:  0.744
Data Source:  BioPlex,STRINGDB
LOXL3
Tchem
Family:  Enzyme
Novelty:  0.03895154
p_int:  0.999581165
p_ni:  0.000418831
p_wrong:  4e-9
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.998976207
p_ni:  0.001023793
Score:  0.574
Data Source:  BioPlex,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.998959819
p_ni:  0.001040181
Score:  0.893
Data Source:  BioPlex,STRINGDB
STX8
Tbio
Novelty:  0.01083752
p_int:  0.995973335
p_ni:  0.004026665
Score:  0.578
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
78.9
mean reticulocyte volume
1
1
1
14.5
mean corpuscular volume
1
1
1
14.5
balding measurement
1
1
1
12.1
educational attainment
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
78.9
mean reticulocyte volume
1
14.5
mean corpuscular volume
1
14.5
balding measurement
1
12.1
educational attainment
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2144243
216705
Rat
RGD:1303328
360515
Dog
clathrin interactor 1
VGNC:39342
479313
Horse
clathrin interactor 1
VGNC:16615
100071176
Cow
clathrin interactor 1
VGNC:27443
538540
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
clathrin interactor 1
Horse
clathrin interactor 1
Cow
clathrin interactor 1
Publication Statistics
PubMed Score 122.13
PubMed score by year
PubTator Score 41.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title