Tbio CLINT1 Clathrin interactor 1

Protein Summary

Description

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q14677
• B7Z6F8
• D3DQJ6
• Q8NAF1
• Q96E05

Gene Name

• CLINT1

Ensembl ID

• ENST00000411809
• ENSP00000388340
• ENSG00000113282
• ENST00000523094
• ENSP00000429345
• ENST00000523908
• ENSP00000429824
• ENST00000530742
• ENSP00000433419

Symbol

• ENTH
• EPN4
• EPNR
• KIAA0171
• ENTH
• EPN4
• EPNR
• CLINT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
ligand (protein) perturbation	0.83
interacting protein	0.8
disease perturbation	0.79
transcription factor binding site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 218   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.13   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0