Tbio CLIC5 Chloride intracellular channel protein 5

Protein Summary

Description

Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9NZA1
• B3KUF1
• Q5T4Z0
• Q8NBY3
• Q96JT5
• Q9BWZ0

Gene Name

• CLIC5

Ensembl ID

• ENST00000185206
• ENSP00000185206
• ENSG00000112782
• ENST00000339561
• ENSP00000344165
• ENST00000544153
• ENSP00000439195

Symbol

• MST130
• DFNB102
• DFNB103
• MSTP130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
protein domain	0.73
PubMedID	0.71
microRNA	0.7
molecular function	0.7

Protein Classes

DTO Classes

Protein / Ion Channel / Intracellular Chloride Channel (Clic) Family / Chloride Intracellular Channel Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.05   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.05   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0