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Tbio
CLIC4
Chloride intracellular channel protein 4

Protein Summary
Description
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374379
  • ENSP00000363500
  • ENSG00000169504
  • ENST00000488683
  • ENSP00000436538

Symbol
  • H1
  • huH1
  • p64H1
  • CLIC4L
  • MTCLIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.97
transcription factor binding site profile
0.95
kinase perturbation
0.93
virus perturbation
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
TPRN
Tbio
Novelty:  0.05784581
p_int:  0.999998902
p_ni:  0.000001098
Score:  0.869
Data Source:  BioPlex,STRINGDB
CLIC5
Tbio
Family:  IC
Novelty:  0.05504841
p_int:  0.999902294
p_ni:  0.000097706
Score:  0.943
Data Source:  BioPlex,STRINGDB
CLIC2
Tbio
Family:  IC
Novelty:  0.03695725
p_int:  0.999747957
p_ni:  1.15e-7
p_wrong:  0.000251929
Score:  0.959
Data Source:  BioPlex,STRINGDB
CLIC6
Tbio
Family:  IC
Novelty:  0.04037074
p_int:  0.970997195
p_ni:  2.8e-8
p_wrong:  0.029002777
Score:  0.853
Data Source:  BioPlex,STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.964471617
p_ni:  0.024503035
p_wrong:  0.011025348
Score:  0.217
Data Source:  BioPlex,STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.873
Data Source:  STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
Score:  0.781
Data Source:  STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
Score:  0.725
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.725
Data Source:  STRINGDB
HIVEP2
Tbio
Family:  TF
Novelty:  0.0290218
Score:  0.715
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
3
3
91.1
5
4
0
1
83.8
lymphocyte count
2
2
2
81.8
platelet crit
2
2
2
80.6
2
2
0
1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
3
91.1
0
1
83.8
lymphocyte count
2
81.8
platelet crit
2
80.6
0
1
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 4
VGNC:10579
749398
Macaque
chloride intracellular channel 4
712337
Mouse
MGI:1352754
29876
Rat
RGD:61857
83718
Dog
chloride intracellular channel 4
VGNC:39340
487367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 4
Macaque
chloride intracellular channel 4
Mouse
Rat
Dog
chloride intracellular channel 4
Publication Statistics
PubMed Score 114.93
PubMed score by year
PubTator Score 54.94
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title