CLIC1
Chloride intracellular channel protein 1
Protein Summary
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
- ENST00000375779
- ENSP00000364934
- ENSG00000213719
- ENST00000375780
- ENSP00000364935
- ENST00000375784
- ENSP00000364940
- ENST00000383404
- ENSP00000372896
- ENSG00000206394
- ENST00000383405
- ENSP00000372897
- ENST00000395892
- ENSP00000379229
- ENST00000400052
- ENSP00000382926
- ENST00000400058
- ENSP00000382931
- ENST00000415179
- ENSP00000409247
- ENSG00000226248
- ENST00000418285
- ENSP00000407791
- ENSG00000226417
- ENST00000420458
- ENSP00000410965
- ENSG00000226651
- ENST00000422167
- ENSP00000407429
- ENST00000423055
- ENSP00000406968
- ENST00000423143
- ENSP00000404589
- ENSG00000223639
- ENST00000423804
- ENSP00000409979
- ENSG00000230685
- ENST00000425464
- ENSP00000401292
- ENST00000431921
- ENSP00000408357
- ENST00000433916
- ENSP00000391395
- ENST00000434202
- ENSP00000400532
- ENST00000435242
- ENSP00000412217
- ENST00000438708
- ENSP00000406088
- ENST00000438750
- ENSP00000404037
- ENST00000442045
- ENSP00000400280
- ENST00000447338
- ENSP00000413330
- ENST00000447369
- ENSP00000408094
- ENST00000451546
- ENSP00000416211
- ENST00000456863
- ENSP00000406335
- ENST00000457485
- ENSP00000398056
- ENST00000614673
- ENSP00000480256
- ENST00000614982
- ENSP00000477623
- ENST00000616760
- ENSP00000479808
- ENST00000618288
- ENSP00000479501
- ENST00000619727
- ENSP00000482255
- ENST00000621055
- ENSP00000478930
- ENST00000622613
- ENSP00000484581
- G6
- NCC27
- G6
- CL1C1
- NCC27
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
PubMedID | 0.91 | ||
virus perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
co-expressed gene | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 263.1 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 393 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 263.1 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 393 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0