You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CLIC1
Chloride intracellular channel protein 1

Protein Summary
Description
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375779
  • ENSP00000364934
  • ENSG00000213719
  • ENST00000375780
  • ENSP00000364935
  • ENST00000375784
  • ENSP00000364940
  • ENST00000383404
  • ENSP00000372896
  • ENSG00000206394
  • ENST00000383405
  • ENSP00000372897
  • ENST00000395892
  • ENSP00000379229
  • ENST00000400052
  • ENSP00000382926
  • ENST00000400058
  • ENSP00000382931
  • ENST00000415179
  • ENSP00000409247
  • ENSG00000226248
  • ENST00000418285
  • ENSP00000407791
  • ENSG00000226417
  • ENST00000420458
  • ENSP00000410965
  • ENSG00000226651
  • ENST00000422167
  • ENSP00000407429
  • ENST00000423055
  • ENSP00000406968
  • ENST00000423143
  • ENSP00000404589
  • ENSG00000223639
  • ENST00000423804
  • ENSP00000409979
  • ENSG00000230685
  • ENST00000425464
  • ENSP00000401292
  • ENST00000431921
  • ENSP00000408357
  • ENST00000433916
  • ENSP00000391395
  • ENST00000434202
  • ENSP00000400532
  • ENST00000435242
  • ENSP00000412217
  • ENST00000438708
  • ENSP00000406088
  • ENST00000438750
  • ENSP00000404037
  • ENST00000442045
  • ENSP00000400280
  • ENST00000447338
  • ENSP00000413330
  • ENST00000447369
  • ENSP00000408094
  • ENST00000451546
  • ENSP00000416211
  • ENST00000456863
  • ENSP00000406335
  • ENST00000457485
  • ENSP00000398056
  • ENST00000614673
  • ENSP00000480256
  • ENST00000614982
  • ENSP00000477623
  • ENST00000616760
  • ENSP00000479808
  • ENST00000618288
  • ENSP00000479501
  • ENST00000619727
  • ENSP00000482255
  • ENST00000621055
  • ENSP00000478930
  • ENST00000622613
  • ENSP00000484581

Symbol
  • G6
  • NCC27
  • G6
  • CL1C1
  • NCC27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
PubMedID
0.91
virus perturbation
0.88
disease perturbation
0.87
co-expressed gene
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.1   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.1   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0