Tbio CLEC9A C-type lectin domain family 9 member A

Protein Summary

Description

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]

Uniprot Accession IDs

• Q6UXN8
• B0ZBM2

Gene Name

• CLEC9A

Ensembl ID

• ENST00000355819
• ENSP00000348074
• ENSG00000197992

Symbol

• CD370
• DNGR1
• DNGR-1
• UNQ9341

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.84
cell type or tissue	0.82
cell line	0.59
protein domain	0.58
biological term	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.96   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 386   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.96   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0