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Tbio
CLEC4C
C-type lectin domain family 4 member C

Protein Summary
Description
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycopr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354629
  • ENSP00000346648
  • ENSG00000198178
  • ENST00000360345
  • ENSP00000353500
  • ENST00000540085
  • ENSP00000445338
  • ENST00000542353
  • ENSP00000440428

Symbol
  • BDCA2
  • CLECSF11
  • CLECSF7
  • DLEC
  • HECL
  • DLEC
  • HECL
  • BDCA2
  • CD303
  • CLECSF7
  • CLECSF11
  • PRO34150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell type or tissue
0.67
protein domain
0.58
cell line
0.57
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0