Tbio CLEC4C C-type lectin domain family 4 member C

Protein Summary

Description

Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WTT0
• D3DUU3
• Q3T1C3
• Q6UXS8
• Q8WXX8

Gene Name

• CLEC4C

Ensembl ID

• ENST00000354629
• ENSP00000346648
• ENSG00000198178
• ENST00000360345
• ENSP00000353500
• ENST00000540085
• ENSP00000445338
• ENST00000542353
• ENSP00000440428

Symbol

• BDCA2
• CLECSF11
• CLECSF7
• DLEC
• HECL
• DLEC
• HECL
• BDCA2
• CD303
• CLECSF7
• CLECSF11
• PRO34150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.71
cell type or tissue	0.67
protein domain	0.58
cell line	0.57
tissue	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member C

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member C

Protein / Cell Adhesion Molecule / C-type Lectin Domain Family 4 Member C

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / C-type Lectin Domain Family 4 Member C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.23   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.23   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0