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Tbio
CLEC4C
C-type lectin domain family 4 member C

Protein Summary
Description
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycopr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354629
  • ENSP00000346648
  • ENSG00000198178
  • ENST00000360345
  • ENSP00000353500
  • ENST00000540085
  • ENSP00000445338
  • ENST00000542353
  • ENSP00000440428

Symbol
  • BDCA2
  • CLECSF11
  • CLECSF7
  • DLEC
  • HECL
  • DLEC
  • HECL
  • BDCA2
  • CD303
  • CLECSF7
  • CLECSF11
  • PRO34150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell type or tissue
0.67
protein domain
0.58
cell line
0.57
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.75   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.75   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999991757
p_ni:  0.000008242
Data Source:  BioPlex
BRF1
Tbio
Novelty:  0.03174992
p_int:  0.996906806
p_ni:  3.17e-7
p_wrong:  0.003092877
Data Source:  BioPlex
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.964214423
p_ni:  0.035513498
p_wrong:  0.000272079
Data Source:  BioPlex
SLC25A6
Tchem
Family:  Transporter
Novelty:  0.0052748
p_int:  0.945077329
p_ni:  0.054922671
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.922027102
p_ni:  0.077972898
Data Source:  BioPlex
SLC25A30
Tdark
Family:  Transporter
Novelty:  0.42665445
p_int:  0.905004593
p_ni:  0.061566901
p_wrong:  0.033428506
Data Source:  BioPlex
SLC25A4
Tbio
Family:  Transporter
Novelty:  0.01250865
p_int:  0.820663181
p_ni:  0.179336819
Data Source:  BioPlex
P30491
Tbio
Novelty:  0.00790207
p_int:  0.767627528
p_ni:  0.232372472
Data Source:  BioPlex
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.756268488
p_ni:  0.243731512
Data Source:  BioPlex
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
62.1
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 108.75
PubMed score by year
PubTator Score 97.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title