Pharos : Target Details

Tdark

Protein Summary

Description

Promotes cell adhesion to laminin-332 and fibronectin.

Uniprot Accession IDs

Gene Name

CLEC3A

Ensembl ID

ENST00000575655
ENSP00000460682
ENSG00000166509

Symbol

CLECSF1
CLECSF1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.67

protein domain	0.58

microRNA	0.57

cell line	0.55

disease	0.55

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.35 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 0 (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.35 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 0 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (110)

Explore Interacting Targets

1 – 10 of 110

See Interactions on String-DB

RNASEH1

Tchem

Family: Enzyme

Novelty: 0.01838314

p_int: 0.999998819

p_ni: 2.7e-8

p_wrong: 0.000001154

Score: 0.19

Data Source: BioPlex,STRINGDB

PHF10

Tbio

Family: Epigenetic

Novelty: 0.05941323

p_int: 0.999993971

p_ni: 0.000006029

Data Source: BioPlex

YY1AP1

Tbio

Novelty: 0.06862573

p_int: 0.999945796

p_ni: 0.000054204

Score: 0.519

Data Source: BioPlex,STRINGDB

ZNF430

Tdark

Family: TF

Novelty: 3.98895047

p_int: 0.999803884

p_ni: 0.000196116

Score: 0.173

Data Source: BioPlex,STRINGDB

CACTIN

Tbio

Novelty: 0.03222124

p_int: 0.99976196

p_ni: 0.000238036

p_wrong: 4e-9

Score: 0.15

Data Source: BioPlex,STRINGDB

RBM23

Tbio

Novelty: 0.03769792

p_int: 0.999735231

p_ni: 0.000264764

p_wrong: 4e-9

Data Source: BioPlex

KBTBD7

Tdark

Novelty: 0.4947466

p_int: 0.999443335

p_ni: 0.000556665

Data Source: BioPlex

CTNNBL1

Tbio

Novelty: 0.0189038

p_int: 0.999133728

p_ni: 0.000591421

p_wrong: 0.000274851

Score: 0.499

Data Source: BioPlex,STRINGDB

LSM14B

Tdark

Novelty: 0.31832554

p_int: 0.999029893

p_ni: 0.000970107

Data Source: BioPlex

C1QBP

Tbio

Novelty: 0.00532825

p_int: 0.997856523

p_ni: 0.002143477

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (1)

Processes (2)

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Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
carbohydrate binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (3)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
self reported educational attainment	EFO_0004784	1	1	1		57.8

eosinophil count	EFO_0004842	2	1	2		46.1

vital capacity	EFO_0004312	1	1	0	16.3	24.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
self reported educational attainment	EFO_0004784	1		57.8

eosinophil count	EFO_0004842	2		46.1

vital capacity	EFO_0004312	0	16.3	24.5

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

Find Similar Targets

No Header	No Header
Complete proteome

Direct protein sequencing

Disulfide bond

Lectin

Polymorphism

Reference proteome

Secreted

Signal

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Mouse	C-type lectin domain family 3, member a	MGI:2685642	403395

Rat	C-type lectin domain family 3, member A	RGD:1306295	365009

Dog	C-type lectin domain family 3 member A	VGNC:39331	610142

Horse	C-type lectin domain family 3 member A	VGNC:16603	100055505

Cow	C-type lectin domain family 3 member A	VGNC:27428	282415

Species	Name	OMA	EggNOG	Inparanoid
Mouse	C-type lectin domain family 3, member a

Rat	C-type lectin domain family 3, member A

Dog	C-type lectin domain family 3 member A

Horse	C-type lectin domain family 3 member A

Cow	C-type lectin domain family 3 member A

Publication Statistics

PubMed Score 7.35

PubMed score by year

PubTator Score 2.29

PubTator score by year

Related Publications

Text Mined References (9)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title