Tbio CLEC2D C-type lectin domain family 2 member D

Protein Summary

Description

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9UHP7
• D6CI39
• D6CI40
• D6CI41
• Q6YID5
• Q8WUP7
• Q9HD37
• Q9HD38

Gene Name

• CLEC2D

Ensembl ID

• ENST00000261339
• ENSP00000261339
• ENSG00000069493
• ENST00000261340
• ENSP00000261340
• ENST00000290855
• ENSP00000290855
• ENST00000479877
• ENSP00000441653
• ENST00000543300
• ENSP00000443065
• ENST00000545918
• ENSP00000444818

Symbol

• CLAX
• LLT1
• OCIL
• CLAX
• LLT1
• OCIL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
microRNA	0.62
PubMedID	0.6
virus perturbation	0.55
tissue	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.84   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 265   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.84   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0