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Tbio
CLEC2D
C-type lectin domain family 2 member D

Protein Summary
Description
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261339
  • ENSP00000261339
  • ENSG00000069493
  • ENST00000261340
  • ENSP00000261340
  • ENST00000290855
  • ENSP00000290855
  • ENST00000479877
  • ENSP00000441653
  • ENST00000543300
  • ENSP00000443065
  • ENST00000545918
  • ENSP00000444818

Symbol
  • CLAX
  • LLT1
  • OCIL
  • CLAX
  • LLT1
  • OCIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
microRNA
0.62
PubMedID
0.6
virus perturbation
0.55
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
DNAJC1
Tbio
Family:  TF
Novelty:  0.07277849
p_int:  0.999986518
p_ni:  0.000013481
Data Source:  BioPlex
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
p_int:  0.999943606
p_ni:  0.000056394
p_wrong:  1e-9
Data Source:  BioPlex
KIAA1586
Tdark
Novelty:  2.30999532
p_int:  0.999456311
p_ni:  0.000543508
p_wrong:  1.81e-7
Data Source:  BioPlex
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
p_int:  0.999089219
p_ni:  0.000835419
p_wrong:  0.000075362
Data Source:  BioPlex
SLC7A3
Tbio
Family:  Transporter
Novelty:  0.00779949
p_int:  0.99876767
p_ni:  0.001229142
p_wrong:  0.000003188
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.998069
p_ni:  0.001930994
p_wrong:  6e-9
Data Source:  BioPlex
ATP8B2
Tbio
Family:  Transporter
Novelty:  0.09269537
p_int:  0.997592935
p_ni:  0.002407065
Data Source:  BioPlex
FAM69A
Tdark
Novelty:  0.35978059
p_int:  0.997426703
p_ni:  0.002573297
Data Source:  BioPlex
NXPE3
Tdark
Novelty:  1.5063521
p_int:  0.996442437
p_ni:  0.002936849
p_wrong:  0.000620713
Data Source:  BioPlex
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.996144026
p_ni:  0.003854811
p_wrong:  0.000001164
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
7
8
99.4
lymphocyte percentage of leukocytes
2
4
5
96.6
neutrophil percentage of leukocytes
2
3
3
89.7
autoimmune thyroid disease
1
3
0
1.1
89.2
3
3
0
1.1
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
8
99.4
lymphocyte percentage of leukocytes
5
96.6
neutrophil percentage of leukocytes
3
89.7
autoimmune thyroid disease
0
1.1
89.2
0
1.1
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-type lectin domain family 2 member D
717228
Mouse
MGI:3028921
232409
Dog
C-type lectin domain family 2 member D
VGNC:39330
611449
Platypus
C-type lectin domain family 2 member D-like
100093116
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-type lectin domain family 2 member D
Mouse
Dog
C-type lectin domain family 2 member D
Platypus
C-type lectin domain family 2 member D-like
Publication Statistics
PubMed Score 48.33
PubMed score by year
PubTator Score 23.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title