You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CLEC2B
C-type lectin domain family 2 member B

Protein Summary
Description
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228438
  • ENSP00000228438
  • ENSG00000110852

Symbol
  • AICL
  • CLECSF2
  • IFNRG1
  • AICL
  • IFNRG1
  • CLECSF2
  • HP10085
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
small molecule perturbation
0.76
gene perturbation
0.72
disease
0.62
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
p_int:  0.999995578
p_ni:  0.000004422
Data Source:  BioPlex
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.999757986
p_ni:  0.000242014
Data Source:  BioPlex
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.999714735
p_ni:  0.000284695
p_wrong:  5.69e-7
Data Source:  BioPlex
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.999301223
p_ni:  0.000698773
p_wrong:  4e-9
Data Source:  BioPlex
USP30
Tchem
Family:  Enzyme
Novelty:  0.03427211
p_int:  0.998472141
p_ni:  0.001527859
Data Source:  BioPlex
EXTL2
Tbio
Family:  Enzyme
Novelty:  0.05051027
p_int:  0.997082401
p_ni:  0.002916588
p_wrong:  0.000001011
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.99364495
p_ni:  0.00635505
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.993206282
p_ni:  0.006793718
Data Source:  BioPlex
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.992736984
p_ni:  0.006532245
p_wrong:  0.000730771
Data Source:  BioPlex
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.991491388
p_ni:  0.008508612
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
6
7
99.3
lymphocyte percentage of leukocytes
2
4
5
96.6
neutrophil percentage of leukocytes
2
3
3
89.7
myeloid white cell count
1
1
1
82.2
leukocyte count
1
2
2
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
7
99.3
lymphocyte percentage of leukocytes
5
96.6
neutrophil percentage of leukocytes
3
89.7
myeloid white cell count
1
82.2
leukocyte count
2
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 2 member B
VGNC:8374
473359
Dog
C-type lectin domain family 2 member B
VGNC:49757
611423
Horse
C-type lectin domain family 2 member B
VGNC:16602
100629907
Pig
C-type lectin domain family 2, member B
100520839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 2 member B
Dog
C-type lectin domain family 2 member B
Horse
C-type lectin domain family 2 member B
Pig
C-type lectin domain family 2, member B
Publication Statistics
PubMed Score 13.71
PubMed score by year
PubTator Score 23.82
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title