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Tbio
CLEC18A
C-type lectin domain family 18 member A

Protein Summary
Description
Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455). This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288040
  • ENSP00000288040
  • ENSG00000157322
  • ENST00000393701
  • ENSP00000377304
  • ENST00000568461
  • ENSP00000454685
  • ENST00000615430
  • ENSP00000484176

Symbol
  • MRLP2
  • MRCL
  • MRCL1
  • MRLP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.61
tissue
0.52
cell line
0.45
transcription factor
0.36


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0