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Tbio
CLEC14A
C-type lectin domain family 14 member A

Protein Summary
Description
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342213
  • ENSP00000353013
  • ENSG00000176435

Symbol
  • C14orf27
  • EGFR5
  • CEG1
  • EGFR-5
  • C14orf27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.72
tissue sample
0.65
protein domain
0.58
disease
0.57
cellular component
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999785628
p_ni:  0.00021437
p_wrong:  2e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
PXK
Tbio
Family:  Kinase
Novelty:  0.02316511
p_int:  0.985016875
p_ni:  0.014983125
Score:  0.345
Data Source:  BioPlex,STRINGDB
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.960734778
p_ni:  0.039246279
p_wrong:  0.000018942
Score:  0.189
Data Source:  BioPlex,STRINGDB
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.818821706
p_ni:  0.179397573
p_wrong:  0.00178072
Score:  0.241
Data Source:  BioPlex,STRINGDB
TCAF1
Tbio
Family:  Enzyme
Novelty:  0.50366212
p_int:  0.815390269
p_ni:  0.184609731
Score:  0.197
Data Source:  BioPlex,STRINGDB
RNGTT
Tbio
Novelty:  0.01433659
Score:  0.904
Data Source:  STRINGDB
MMRN2
Tbio
Novelty:  0.11135003
Score:  0.868
Data Source:  STRINGDB
RNMT
Tchem
Family:  Enzyme
Novelty:  0.00880207
Score:  0.801
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.755
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.709
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
4
2
1
81.6
hemoglobin A1 measurement
1
1
1
13.3
5-HIAA measurement
1
1
1
7.6
MHPG measurement
1
1
1
7.6
Drugs used in diabetes use measurement
2
1
2
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1
81.6
hemoglobin A1 measurement
1
13.3
5-HIAA measurement
1
7.6
MHPG measurement
1
7.6
Drugs used in diabetes use measurement
2
0.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 14A
VGNC:48894
467435
Mouse
MGI:1914114
66864
Rat
RGD:1306232
314148
Dog
C-type lectin domain containing 14A
VGNC:39327
490660
Cow
C-type lectin domain containing 14A
VGNC:27425
509367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 14A
Mouse
Rat
Dog
C-type lectin domain containing 14A
Cow
C-type lectin domain containing 14A
Publication Statistics
PubMed Score 42.20
PubMed score by year
PubTator Score 21.28
PubTator score by year
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Related Publications
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PMID
Year
Title