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Tbio
CLDN6
Claudin-6

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328796
  • ENSP00000328674
  • ENSG00000184697
  • ENST00000396925
  • ENSP00000380131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
PubMedID
0.67
cell type or tissue
0.65
ligand (protein) perturbation
0.59
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.74   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 503   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.74   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 503   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.961
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.924
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.92
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.917
Data Source:  STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
Score:  0.912
Data Source:  STRINGDB
CLDN10
Tbio
Novelty:  0.02175843
Score:  0.911
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.91
Data Source:  STRINGDB
CLDN19
Tbio
Novelty:  0.02391772
Score:  0.909
Data Source:  STRINGDB
CLDN4
Tbio
Novelty:  0.00227337
Score:  0.909
Data Source:  STRINGDB
CLDN3
Tbio
Novelty:  0.00286252
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
56.7
serum alanine aminotransferase measurement
1
1
1
22.5
brain measurement
1
1
0
5.8
18.4
balding measurement
1
1
1
17.6
sex hormone-binding globulin measurement
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
56.7
serum alanine aminotransferase measurement
1
22.5
brain measurement
0
5.8
18.4
balding measurement
1
17.6
sex hormone-binding globulin measurement
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
claudin 6
699854
Mouse
MGI:1859284
54419
Rat
RGD:1308837
287098
Dog
claudin 6
VGNC:39322
490048
Cow
claudin 6
VGNC:27418
511318
Species
Name
OMA
EggNOG
Inparanoid
Macaque
claudin 6
Mouse
Rat
Dog
claudin 6
Cow
claudin 6
Publication Statistics
PubMed Score 86.74
PubMed score by year
PubTator Score 32.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title