Tbio CLDN3 Claudin-3

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15551

Gene Name

• CLDN3

Ensembl ID

• ENST00000395145
• ENSP00000378577
• ENSG00000165215

Symbol

• C7orf1
• CPETR2
• RVP1
• HRVP1
• C7orf1
• CPE-R2
• CPETR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.88
disease	0.73
transcription factor binding site profile	0.63
histone modification site profile	0.61

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-3

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.95   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 521   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.95   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0