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Tbio
CLDN19
Claudin-19

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296387
  • ENSP00000296387
  • ENSG00000164007
  • ENST00000372539
  • ENSP00000361617
  • ENST00000539749
  • ENSP00000443229

Symbol
  • HOMG5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.68
gene perturbation
0.53
transcription factor
0.49
cellular component
0.48
pathway
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.33   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.33   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
STIM1
Tbio
Novelty:  0.00116516
p_int:  0.998646829
p_ni:  0.001353171
Data Source:  BioPlex
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.982771766
p_ni:  0.017228152
p_wrong:  8.2e-8
Data Source:  BioPlex
RAD23A
Tbio
Novelty:  0.01603801
p_int:  0.802292935
p_ni:  0.197707065
Data Source:  BioPlex
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.958
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.957
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.939
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.916
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.916
Data Source:  STRINGDB
CLDN22
Tdark
Novelty:  3.48888141
Score:  0.91
Data Source:  STRINGDB
CLDN6
Tbio
Novelty:  0.01814018
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 19
VGNC:10578
101059009
Mouse
MGI:3033992
242653
Rat
RGD:1305000
298487
Dog
claudin 19
VGNC:39315
607005
Horse
claudin 19
VGNC:16590
100053591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 19
Mouse
Rat
Dog
claudin 19
Horse
claudin 19
Publication Statistics
PubMed Score 45.33
PubMed score by year
PubTator Score 36.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title