Protein Summary
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
- ENST00000296387
- ENSP00000296387
- ENSG00000164007
- ENST00000372539
- ENSP00000361617
- ENST00000539749
- ENSP00000443229
- HOMG5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.68 | ||
gene perturbation | 0.53 | ||
transcription factor | 0.49 | ||
cellular component | 0.48 | ||
pathway | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.33 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.33 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
IGSF8
Novelty: 0.03016623
p_int: 0.982771766
p_ni: 0.017228152
p_wrong: 8.2e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (9)
Reactome (4)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | claudin 19 | VGNC:10578 | 101059009 | |||||
Mouse | MGI:3033992 | 242653 | ||||||
Rat | RGD:1305000 | 298487 | ||||||
Dog | claudin 19 | VGNC:39315 | 607005 | |||||
Horse | claudin 19 | VGNC:16590 | 100053591 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | claudin 19 | |||||
Mouse | ||||||
Rat | ||||||
Dog | claudin 19 | |||||
Horse | claudin 19 | |||||
Publication Statistics
PubMed Score 45.33
PubMed score by year
PubTator Score 36.02
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (11)
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