Tbio CLDN18 Claudin-18

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P56856
• A5PL21
• Q96PH4

Gene Name

• CLDN18

Ensembl ID

• ENST00000183605
• ENSP00000183605
• ENSG00000066405
• ENST00000343735
• ENSP00000340939

Symbol

• SFTA5
• SFTPJ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.66
tissue sample	0.66
cell type or tissue	0.63
protein domain	0.58
virus perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-18

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.06   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.06   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0