Protein Summary
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
- ENST00000183605
- ENSP00000183605
- ENSG00000066405
- ENST00000343735
- ENSP00000340939
- SFTA5
- SFTPJ
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.66 | ||
tissue sample | 0.66 | ||
cell type or tissue | 0.63 | ||
protein domain | 0.58 | ||
virus perturbation | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.11 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 95.11 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
THEM4
Family: Enzyme
Novelty: 0.0191855
p_int: 0.942753534
p_ni: 0.05678743
p_wrong: 0.000459036
Score: 0.332
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (50)
Reactome (4)
KEGG (4)
WikiPathways (42)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 1 | 2 | 36.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 36.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | claudin 18 | VGNC:1783 | 470935 | |||||
Macaque | claudin 18 | 716628 | ||||||
Mouse | MGI:1929209 | 56492 | ||||||
Rat | RGD:1359696 | 315953 | ||||||
Dog | claudin 18 | VGNC:39314 | 477079 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | claudin 18 | |||||
Macaque | claudin 18 | |||||
Mouse | ||||||
Rat | ||||||
Dog | claudin 18 | |||||
Publication Statistics
PubMed Score 95.11
PubMed score by year
PubTator Score 45.02
PubTator score by year
Related Publications
Text Mined References (39)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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