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Tbio
CLDN17
Claudin-17

Protein Summary
Description
Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286808
  • ENSP00000286808
  • ENSG00000156282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
tissue
0.54
cell line
0.51
small molecule perturbation
0.51
pathway
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999630951
p_ni:  0.000345874
p_wrong:  0.000023175
Data Source:  BioPlex
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.963
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.96
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.917
Data Source:  STRINGDB
CLDN10
Tbio
Novelty:  0.02175843
Score:  0.913
Data Source:  STRINGDB
CLDN22
Tdark
Novelty:  3.48888141
Score:  0.912
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.911
Data Source:  STRINGDB
CLDN15
Tbio
Novelty:  0.02763602
Score:  0.91
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.91
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
68.8
smoking status measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
68.8
smoking status measurement
1
0.4
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 17
VGNC:1156
474084
Macaque
claudin 17
705582
Mouse
MGI:2652030
239931
Rat
RGD:1307462
304125
Dog
claudin 17
VGNC:39313
487720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 17
Macaque
claudin 17
Mouse
Rat
Dog
claudin 17
Publication Statistics
PubMed Score 4.31
PubMed score by year
PubTator Score 2.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title