You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CLDN16
Claudin-16

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264734
  • ENSP00000264734
  • ENSG00000113946

Symbol
  • PCLN1
  • HOMG3
  • PCLN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
microRNA
0.67
protein domain
0.58
cell type or tissue
0.54
molecular function
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.01   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.01   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.961
Data Source:  STRINGDB
CLDN17
Tbio
Novelty:  0.23348754
Score:  0.96
Data Source:  STRINGDB
CLDN19
Tbio
Novelty:  0.02391772
Score:  0.957
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.942
Data Source:  STRINGDB
CLDN14
Tbio
Novelty:  0.02142511
Score:  0.935
Data Source:  STRINGDB
CLDN8
Tbio
Novelty:  0.02218455
Score:  0.926
Data Source:  STRINGDB
CLDN3
Tbio
Novelty:  0.00286252
Score:  0.926
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.926
Data Source:  STRINGDB
CLDN10
Tbio
Novelty:  0.02175843
Score:  0.924
Data Source:  STRINGDB
CLDN5
Tbio
Novelty:  0.00174396
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 16
VGNC:1781
740268
Macaque
claudin 16
704442
Mouse
MGI:2148742
114141
Rat
RGD:620322
155268
Dog
claudin 16
VGNC:39312
608218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 16
Macaque
claudin 16
Mouse
Rat
Dog
claudin 16
Publication Statistics
PubMed Score 118.01
PubMed score by year
PubTator Score 84.46
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title