You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CLDN11
Claudin-11

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000064724
  • ENSP00000064724
  • ENSG00000013297

Symbol
  • OSP
  • OTM
  • OSP
  • OTM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
microRNA
0.77
small molecule perturbation
0.69
PubMedID
0.68
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.21   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.21   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.956
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.947
Data Source:  STRINGDB
CLDN14
Tbio
Novelty:  0.02142511
Score:  0.922
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.92
Data Source:  STRINGDB
CLDN5
Tbio
Novelty:  0.00174396
Score:  0.919
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.917
Data Source:  STRINGDB
CLDN6
Tbio
Novelty:  0.01814018
Score:  0.917
Data Source:  STRINGDB
CLDN9
Tbio
Novelty:  0.06435094
Score:  0.916
Data Source:  STRINGDB
CLDN3
Tbio
Novelty:  0.00286252
Score:  0.916
Data Source:  STRINGDB
CLDN19
Tbio
Novelty:  0.02391772
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.2
83
glomerular filtration rate
3
2
3
31.3
creatinine measurement
2
1
2
17.8
aspartate aminotransferase measurement
1
1
0
6.1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83
glomerular filtration rate
3
31.3
creatinine measurement
2
17.8
aspartate aminotransferase measurement
0
6.1
8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 11
VGNC:1780
460846
Macaque
claudin 11
696363
Mouse
MGI:106925
18417
Rat
RGD:71081
84588
Dog
claudin 11
VGNC:49935
488160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 11
Macaque
claudin 11
Mouse
Rat
Dog
claudin 11
Publication Statistics
PubMed Score 381.21
PubMed score by year
PubTator Score 119.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title