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Tbio
CLDN10
Claudin-10

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597). This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintain ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299339
  • ENSP00000299339
  • ENSG00000134873
  • ENST00000376873
  • ENSP00000366069

Symbol
  • OSPL
  • HELIX
  • OSP-L
  • CPETRL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
kinase perturbation
0.71
PubMedID
0.7
microRNA
0.64
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.05   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.05   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
FGF1
Tchem
Novelty:  0.00055979
p_int:  0.99819635
p_ni:  0.001793078
p_wrong:  0.000010572
Score:  0.269
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.964223017
p_ni:  0.035776983
Score:  0.295
Data Source:  BioPlex,STRINGDB
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.95
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.947
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.934
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.924
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.915
Data Source:  STRINGDB
CLDN2
Tbio
Novelty:  0.00299455
Score:  0.914
Data Source:  STRINGDB
CLDN17
Tbio
Novelty:  0.23348754
Score:  0.913
Data Source:  STRINGDB
CLDN14
Tbio
Novelty:  0.02142511
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 10
VGNC:13072
452626
Macaque
claudin 10
695638
Mouse
MGI:1913101
58187
Rat
RGD:1308027
290485
Dog
claudin 10
VGNC:39309
476963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 10
Macaque
claudin 10
Mouse
Rat
Dog
claudin 10
Publication Statistics
PubMed Score 49.05
PubMed score by year
PubTator Score 26.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title