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Tbio
CLCN5
H(+)/Cl(-) exchange transporter 5

Protein Summary
Description
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307367
  • ENSP00000304257
  • ENSG00000171365
  • ENST00000376088
  • ENSP00000365256
  • ENST00000376091
  • ENSP00000365259
  • ENST00000376108
  • ENSP00000365276
  • ENST00000642885
  • ENSP00000496632

Symbol
  • CLCK2
  • XRN
  • CLC5
  • XLRH
  • CLCK2
  • ClC-5
  • DENTS
  • NPHL1
  • NPHL2
  • hCIC-K2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.97
kinase perturbation
0.95
small molecule perturbation
0.87
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.3   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.3   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999999995
p_ni:  5e-9
Score:  0.412
Data Source:  BioPlex,STRINGDB
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.999999925
p_ni:  1.8e-8
p_wrong:  5.7e-8
Score:  0.475
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999964426
p_ni:  1.67e-7
p_wrong:  0.000035406
Score:  0.183
Data Source:  BioPlex,STRINGDB
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999910019
p_ni:  0.00008998
p_wrong:  1e-9
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.85305371
p_ni:  0.14694629
Data Source:  BioPlex
SELENOS
Tbio
Novelty:  0.01108715
p_int:  0.782024036
p_ni:  0.000653104
p_wrong:  0.217322859
Data Source:  BioPlex
LRP2
Tbio
Novelty:  0.00143258
Score:  0.81
Data Source:  STRINGDB
BSND
Tbio
Novelty:  0.01638636
Score:  0.801
Data Source:  STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
Score:  0.799
Data Source:  STRINGDB
KIF3B
Tbio
Novelty:  0.01877656
Score:  0.775
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
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10
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GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 5
VGNC:12255
104003900
Macaque
chloride voltage-gated channel 5
694497
Mouse
MGI:99486
12728
Rat
RGD:2362
25749
Dog
chloride voltage-gated channel 5
VGNC:39305
491882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride voltage-gated channel 5
Macaque
chloride voltage-gated channel 5
Mouse
Rat
Dog
chloride voltage-gated channel 5
Publication Statistics
PubMed Score 263.30
PubMed score by year
PubTator Score 162.31
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title