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Tbio
CLCN5
H(+)/Cl(-) exchange transporter 5

Protein Summary
Description
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307367
  • ENSP00000304257
  • ENSG00000171365
  • ENST00000376088
  • ENSP00000365256
  • ENST00000376091
  • ENSP00000365259
  • ENST00000376108
  • ENSP00000365276
  • ENST00000642885
  • ENSP00000496632

Symbol
  • CLCK2
  • XRN
  • CLC5
  • XLRH
  • CLCK2
  • ClC-5
  • DENTS
  • NPHL1
  • NPHL2
  • hCIC-K2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.97
kinase perturbation
0.95
small molecule perturbation
0.87
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.12   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.12   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0