Tbio CLCN3 H(+)/Cl(-) exchange transporter 3

Protein Summary

Description

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P51790
• B7Z932
• B9EGJ9
• D3DP34
• E9PB97
• O14918
• Q86Z21

Gene Name

• CLCN3

Ensembl ID

• ENST00000347613
• ENSP00000261514
• ENSG00000109572
• ENST00000360642
• ENSP00000353857
• ENST00000513761
• ENSP00000424603

Symbol

• CLC3
• ClC-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
molecular function	1
virus perturbation	1
co-expressed gene	0.98

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Anion Channel / H(+)/cl(-) Exchange Transporter 3

DTO Classes

Protein / Ion Channel / Chloride Channel Family / Clc-3/clcn3 Subfamily / H(+)/cl(-) Exchange Transporter 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.65   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.65   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0