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Tbio
CLASRP
CLK4-associating serine/arginine rich protein

Protein Summary
Description
Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391952
  • ENSP00000375814
  • ENSG00000104859
  • ENST00000391953
  • ENSP00000375815

Symbol
  • SFRS16
  • SWAP2
  • CLASP
  • SWAP2
  • SFRS16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.94
hub protein
0.71
tissue sample
0.69
cell line
0.63
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.77   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.77   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
ATXN1L
Tbio
Novelty:  0.1105313
p_int:  0.999999969
p_ni:  1.9e-8
p_wrong:  1.2e-8
Score:  0.233
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.999999444
p_ni:  5.56e-7
Score:  0.192
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.999999233
p_ni:  7.67e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
TMEM184B
Tdark
Novelty:  0.35340207
p_int:  0.999998372
p_ni:  0.000001628
Data Source:  BioPlex
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.999995925
p_ni:  0.000004075
Score:  0.35
Data Source:  BioPlex,STRINGDB
ATXN1
Tbio
Novelty:  0.00419081
p_int:  0.999984286
p_ni:  7.4e-8
p_wrong:  0.00001564
Score:  0.214
Data Source:  BioPlex,STRINGDB
WSB2
Tbio
Novelty:  0.03939755
p_int:  0.999981217
p_ni:  0.000018739
p_wrong:  4.3e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.999972005
p_ni:  0.000027793
p_wrong:  2.03e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.999000014
p_ni:  0.000999304
p_wrong:  6.82e-7
Score:  0.75
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
19
19
99.9
low density lipoprotein cholesterol measurement
4
17
18
15.3
99.9
total cholesterol measurement
3
14
15
99.9
2
18
0
7
98.4
family history of Alzheimer’s disease
1
15
0
7.6
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
19
99.9
low density lipoprotein cholesterol measurement
18
15.3
99.9
total cholesterol measurement
15
99.9
0
7
98.4
family history of Alzheimer’s disease
0
7.6
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CLK4 associating serine/arginine rich protein
VGNC:10274
456120
Macaque
CLK4 associating serine/arginine rich protein
713561
Mouse
MGI:1855695
53609
Rat
RGD:1563538
499390
Horse
CLK4 associating serine/arginine rich protein
VGNC:16569
100065554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CLK4 associating serine/arginine rich protein
Macaque
CLK4 associating serine/arginine rich protein
Mouse
Rat
Horse
CLK4 associating serine/arginine rich protein
Publication Statistics
PubMed Score 161.77
PubMed score by year
PubTator Score 22.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title