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Tbio
CKMT2
Creatine kinase S-type, mitochondrial

Protein Summary
Description
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254035
  • ENSP00000254035
  • ENSG00000131730
  • ENST00000424301
  • ENSP00000404203
  • ENST00000437669
  • ENSP00000410289

Symbol
  • SMTCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.73
cellular component
0.63
gene perturbation
0.53
tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CKMT1A
Tbio
Family:  Kinase
Novelty:  0.00844533
p_int:  1
Score:  0.692
Data Source:  BioPlex,STRINGDB
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999983432
p_ni:  0.000012253
p_wrong:  0.000004315
Score:  0.882
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.909750441
p_ni:  0.09015394
p_wrong:  0.000095619
Data Source:  BioPlex
GAMT
Tbio
Family:  Enzyme
Novelty:  0.00656642
Score:  0.96
Data Source:  STRINGDB
MB
Tbio
Novelty:  0.00008405
Score:  0.878
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.854
Data Source:  STRINGDB
LDHAL6A
Tbio
Family:  Enzyme
Novelty:  0.01301939
Score:  0.774
Data Source:  STRINGDB
LDHAL6B
Tbio
Family:  Enzyme
Novelty:  0.00801753
Score:  0.748
Data Source:  STRINGDB
LDHC
Tbio
Family:  Enzyme
Novelty:  0.00213484
Score:  0.722
Data Source:  STRINGDB
LDHB
Tchem
Family:  Enzyme
Novelty:  0.00242213
Score:  0.698
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Creatine metabolism (R-HSA-71288)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Creatine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Creatine metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
creatine kinase, mitochondrial 2
VGNC:3952
461770
Macaque
creatine kinase, mitochondrial 2
711434
Mouse
MGI:1923972
76722
Dog
creatine kinase, mitochondrial 2
VGNC:39292
479163
Horse
creatine kinase, mitochondrial 2
VGNC:16565
100073253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
creatine kinase, mitochondrial 2
Macaque
creatine kinase, mitochondrial 2
Mouse
Dog
creatine kinase, mitochondrial 2
Horse
creatine kinase, mitochondrial 2
Publication Statistics
PubMed Score 102.07
PubMed score by year
PubTator Score 20.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title