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Tbio
CKM
Creatine kinase M-type

Protein Summary
Description
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221476
  • ENSP00000221476
  • ENSG00000104879

Symbol
  • CKMM
  • CKMM
  • M-CK
  • CPK-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.9
disease
0.79
disease perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.78   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 789   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.78   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 789   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999999952
p_ni:  4.8e-8
Data Source:  BioPlex
CKB
Tbio
Family:  Kinase
Novelty:  0.00347535
p_int:  0.999999949
p_ni:  5.1e-8
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999999918
p_ni:  3.7e-8
p_wrong:  4.5e-8
Data Source:  BioPlex
CKMT2
Tbio
Family:  Kinase
Novelty:  0.00904745
p_int:  0.999983432
p_ni:  0.000012253
p_wrong:  0.000004315
Score:  0.882
Data Source:  BioPlex,STRINGDB
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  0.999978786
p_ni:  0.000021192
p_wrong:  2.2e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999973821
p_ni:  0.000019674
p_wrong:  0.000006505
Data Source:  BioPlex
ZDHHC7
Tbio
Family:  Enzyme
Novelty:  0.07453193
p_int:  0.999969068
p_ni:  0.00003092
p_wrong:  1.1e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999969002
p_ni:  0.000030904
p_wrong:  9.4e-8
Data Source:  BioPlex
CRYGN
Tdark
Novelty:  0.29650893
p_int:  0.999509475
p_ni:  0.000395209
p_wrong:  0.000095316
Data Source:  BioPlex
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.998891236
p_ni:  0.001108756
p_wrong:  8e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Creatine metabolism (R-HSA-71288)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Creatine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Creatine metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
mean platelet volume
4
3
5
98
platelet count
3
6
5
2.6
97.9
leukocyte count
2
3
3
97.4
monocyte count
2
2
2
95.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
mean platelet volume
5
98
platelet count
5
2.6
97.9
leukocyte count
3
97.4
monocyte count
2
95.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
creatine kinase, M-type
VGNC:7552
744935
Mouse
MGI:88413
12715
Rat
RGD:2358
24265
Dog
creatine kinase, M-type
VGNC:39291
476435
Horse
creatine kinase, M-type
VGNC:16564
100065641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
creatine kinase, M-type
Mouse
Rat
Dog
creatine kinase, M-type
Horse
creatine kinase, M-type
Publication Statistics
PubMed Score 391.78
PubMed score by year
PubTator Score 294.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text