Tbio CKM Creatine kinase M-type

Protein Summary

Description

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P06732
• Q96QL9

Gene Name

• CKM

Ensembl ID

• ENST00000221476
• ENSP00000221476
• ENSG00000104879

Symbol

• CKMM
• CKMM
• M-CK
• CPK-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
molecular function	0.9
disease	0.79
disease perturbation	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Amino Acid Kinase / Creatine Kinase M-type

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Atp:guanido Phosphotransferase Family / Creatine Kinase M-type

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.78   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 789   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.78   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 789   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (98)

Explore Interacting Targets

1 – 10 of 98

• See Interactions on String-DB

MECOM

Tbio

Family:  TF; Epigenetic

Novelty:  0.00500501

p_int:  0.999999952

p_ni:  4.8e-8

Data Source:  BioPlex

CKB

Tbio

Family:  Kinase

Novelty:  0.00347535

p_int:  0.999999949

p_ni:  5.1e-8

Score:  0.985

Data Source:  BioPlex,Reactome,STRINGDB

RSPH6A

Tdark

Novelty:  0.03734897

p_int:  0.999999918

p_ni:  3.7e-8

p_wrong:  4.5e-8

Data Source:  BioPlex

CKMT2

Tbio

Family:  Kinase

Novelty:  0.00904745

p_int:  0.999983432

p_ni:  0.000012253

p_wrong:  0.000004315

Score:  0.882

Data Source:  BioPlex,STRINGDB

AKAP17A

Tbio

Family:  Enzyme

Novelty:  0.02860381

p_int:  0.999978786

p_ni:  0.000021192

p_wrong:  2.2e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

PSMB9

Tchem

Family:  Enzyme

Novelty:  0.0016249

p_int:  0.999973821

p_ni:  0.000019674

p_wrong:  0.000006505

Data Source:  BioPlex

ZDHHC7

Tbio

Family:  Enzyme

Novelty:  0.07453193

p_int:  0.999969068

p_ni:  0.00003092

p_wrong:  1.1e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

LZTR1

Tbio

Novelty:  0.02363333

p_int:  0.999969002

p_ni:  0.000030904

p_wrong:  9.4e-8

Data Source:  BioPlex

CRYGN

Tdark

Novelty:  0.29650893

p_int:  0.999509475

p_ni:  0.000395209

p_wrong:  0.000095316

Data Source:  BioPlex

ATP6V1C2

Tbio

Family:  Enzyme

Novelty:  0.07583427

p_int:  0.998891236

p_ni:  0.001108756

p_wrong:  8e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (20)

Reactome (3)

KEGG (2)

PathwayCommons (3)

WikiPathways (12)

Creatine metabolism (R-HSA-71288)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Creatine metabolism	10 targets	R-HSA-71288
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Name	Explore in Pharos	Explore in Source
Creatine metabolism	10 targets	R-HSA-71288
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (2)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
creatine kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (43)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 43

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatine kinase measurement	EFO_0004534	4	4	7		98.4
mean platelet volume	EFO_0004584	4	3	5		98
platelet count	EFO_0004309	3	6	5	2.6	97.9
leukocyte count	EFO_0004308	2	3	3		97.4
monocyte count	EFO_0005091	2	2	2		95.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatine kinase measurement	EFO_0004534	7		98.4
mean platelet volume	EFO_0004584	5		98
platelet count	EFO_0004309	5	2.6	97.9
leukocyte count	EFO_0004308	3		97.4
monocyte count	EFO_0005091	2		95.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
apolipoprotein B measurement
basophil count
body height
body mass index
C-reactive protein measurement
cognitive function measurement
coronary artery disease
creatine kinase measurement
eosinophil count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	creatine kinase, M-type	VGNC:7552	744935
Mouse	creatine kinase, muscle	MGI:88413	12715
Rat	creatine kinase, M-type	RGD:2358	24265
Dog	creatine kinase, M-type	VGNC:39291	476435
Horse	creatine kinase, M-type	VGNC:16564	100065641

Species	Name	OMA	EggNOG	Inparanoid
Chimp	creatine kinase, M-type
Mouse	creatine kinase, muscle
Rat	creatine kinase, M-type
Dog	creatine kinase, M-type
Horse	creatine kinase, M-type

Publication Statistics

PubMed Score 391.78

PubMed score by year

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PubTator Score 294.73

PubTator score by year

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Related Publications

GeneRif Annotations (67)

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