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Tbio
CITED4
Cbp/p300-interacting transactivator 4

Protein Summary
Description
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372638
  • ENSP00000361721
  • ENSG00000179862

Symbol
  • MRG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor binding site profile
0.68
histone modification site profile
0.64
transcription factor
0.59
small molecule perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.66   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.66   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.974
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.96
Data Source:  Reactome,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.954
Data Source:  Reactome,STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.947
Data Source:  Reactome,STRINGDB
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
Score:  0.931
Data Source:  Reactome,STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.92
Data Source:  STRINGDB
TFAP2E
Tbio
Family:  TF
Novelty:  0.07487225
Score:  0.9
Data Source:  STRINGDB
TFAP2D
Tdark
Family:  TF
Novelty:  0.18255944
Score:  0.9
Data Source:  STRINGDB
ZNF565
Tdark
Family:  TF
Novelty:  4.65230769
Score:  0.574
Data Source:  STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
Score:  0.551
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
72
77.9
neutrophil count
2
2
2
59.5
monocyte count
1
1
1
38
balding measurement
1
1
1
32.9
QT interval
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
72
77.9
neutrophil count
2
59.5
monocyte count
1
38
balding measurement
1
32.9
QT interval
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
VGNC:14807
746795
Mouse
MGI:1861694
56222
Rat
RGD:620113
114491
Cow
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
VGNC:27378
504742
Opossum
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
103095664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Mouse
Rat
Cow
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Opossum
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Publication Statistics
PubMed Score 16.66
PubMed score by year
PubTator Score 9.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title