CITED2
Cbp/p300-interacting transactivator 2
Protein Summary
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plat ...more
- ENST00000367651
- ENSP00000356623
- ENSG00000164442
- ENST00000536159
- ENSP00000442831
- ENST00000618718
- ENSP00000479918
- MRG1
- ASD8
- MRG1
- VSD2
- MRG-1
- P35SRJ
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor binding site profile | 0.99 | ||
biological process | 0.98 | ||
transcription factor perturbation | 0.94 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.59 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 214 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.59 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 214 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
Nearest Tclin Targets
Pathways (16)
Reactome (12)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the TFAP2 (AP-2) family of transcription factors | ||||
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | FOXO-mediated transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the TFAP2 (AP-2) family of transcription factors | ||||
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
FOXO-mediated transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (44)
Functions (7)
Components (5)
Processes (32)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 2 | 3 | 3 | 66.8 | |||||
heel bone mineral density | 2 | 2 | 2 | 59.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 53.3 | |||||
mean corpuscular volume | 1 | 1 | 1 | 42.3 | |||||
albumin:globulin ratio measurement | 1 | 1 | 1 | 8 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 3 | 66.8 | |||||
heel bone mineral density | 2 | 59.5 | |||||
mean reticulocyte volume | 1 | 53.3 | |||||
mean corpuscular volume | 1 | 42.3 | |||||
albumin:globulin ratio measurement | 1 | 8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | 707729 | ||||||
Mouse | MGI:1306784 | 17684 | ||||||
Rat | RGD:620112 | 114490 | ||||||
Dog | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | VGNC:39284 | 484010 | |||||
Cow | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | VGNC:27377 | 521378 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | |||||
Cow | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | |||||
Publication Statistics
PubMed Score 126.59
PubMed score by year
PubTator Score 69.57
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (37)
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0 of 0
PMID | Year | Title |
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