You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CITED1
Cbp/p300-interacting transactivator 1

Protein Summary
Description
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246139
  • ENSP00000246139
  • ENSG00000125931
  • ENST00000373619
  • ENSP00000362721
  • ENST00000431381
  • ENSP00000388548
  • ENST00000445983
  • ENSP00000403274
  • ENST00000453707
  • ENSP00000401764

Symbol
  • MSG1
  • MSG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.93
molecular function
0.86
histone modification site profile
0.81
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
p_int:  0.999999993
p_ni:  7e-9
Score:  0.954
Data Source:  BioPlex,Reactome,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
p_int:  0.999999991
p_ni:  9e-9
Score:  0.951
Data Source:  BioPlex,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.381
Data Source:  BioPlex,STRINGDB
RBL2
Tbio
Novelty:  0.00121893
p_int:  0.999998904
p_ni:  0.000001095
p_wrong:  1e-9
Data Source:  BioPlex
RB1
Tchem
Novelty:  0.00063798
p_int:  0.999931409
p_ni:  0.000068591
Data Source:  BioPlex
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.99979397
p_ni:  0.00020603
Data Source:  BioPlex
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.99967092
p_ni:  0.00032908
Data Source:  BioPlex
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.994222093
p_ni:  0.005777907
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.991803272
p_ni:  0.008147002
p_wrong:  0.000049725
Data Source:  BioPlex
RLIM
Tbio
Family:  Enzyme
Novelty:  0.02267745
p_int:  0.98929599
p_ni:  0.01070401
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (53)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
46.9
sodium measurement
1
1
1
42.2
chloride measurement
1
1
1
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
46.9
sodium measurement
1
42.2
chloride measurement
1
33
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
465711
Macaque
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
703165
Mouse
MGI:108023
12705
Rat
RGD:620781
64466
Dog
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
VGNC:39283
100855937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Macaque
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Mouse
Rat
Dog
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Publication Statistics
PubMed Score 52.76
PubMed score by year
PubTator Score 40.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title