Tbio CITED1 Cbp/p300-interacting transactivator 1

Protein Summary

Description

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q99966
• B5BU50
• B5BUI2

Gene Name

• CITED1

Ensembl ID

• ENST00000246139
• ENSP00000246139
• ENSG00000125931
• ENST00000373619
• ENSP00000362721
• ENST00000431381
• ENSP00000388548
• ENST00000445983
• ENSP00000403274
• ENST00000453707
• ENSP00000401764

Symbol

• MSG1
• MSG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	0.93
molecular function	0.86
histone modification site profile	0.81
PubMedID	0.81

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cbp/p300-interacting Transactivator 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Cbp/p300-interacting Transactivator 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.12   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.12   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0