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Tbio
CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

Protein Summary
Description
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613478
  • ENSP00000483781
  • ENSG00000277972
  • ENST00000620783
  • ENSP00000484950
  • ENSG00000274768

Symbol
  • MiNT
  • Miner2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
cell line
0.55
microRNA
0.54
transcription factor
0.53
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.05   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.05   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.998469014
p_ni:  0.000624022
p_wrong:  0.000906964
Data Source:  BioPlex
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.997087206
p_ni:  0.002892212
p_wrong:  0.000020582
Score:  0.187
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.933719171
p_ni:  0.000595959
p_wrong:  0.06568487
Score:  0.177
Data Source:  BioPlex,STRINGDB
SMOC1
Tbio
Novelty:  0.03819681
p_int:  0.919004756
p_ni:  0.080994364
p_wrong:  8.79e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.893938734
p_ni:  0.002090882
p_wrong:  0.103970384
Score:  0.183
Data Source:  BioPlex,STRINGDB
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.753053781
p_ni:  0.001199446
p_wrong:  0.245746773
Score:  0.186
Data Source:  BioPlex,STRINGDB
CISD1
Tchem
Novelty:  0.0118675
Score:  0.945
Data Source:  STRINGDB
CISD2
Tbio
Novelty:  0.01665752
Score:  0.883
Data Source:  STRINGDB
ARHGAP23
Tdark
Family:  Enzyme
Novelty:  0.41444663
Score:  0.45
Data Source:  STRINGDB
KCTD21
Tbio
Novelty:  1.05252269
Score:  0.446
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
FEV/FEC ratio
1
78.4
body height
2
68
body height
2
68
heel bone mineral density
2
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:101788
217149
Dog
CDGSH iron sulfur domain 3
VGNC:39280
491036
Horse
CDGSH iron sulfur domain 3
VGNC:16557
100146123
Cow
CDGSH iron sulfur domain 3
VGNC:27373
618350
Xenopus
CDGSH iron sulfur domain 3
XB-GENE-5954062
100127760
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
CDGSH iron sulfur domain 3
Horse
CDGSH iron sulfur domain 3
Cow
CDGSH iron sulfur domain 3
Xenopus
CDGSH iron sulfur domain 3
Publication Statistics
PubMed Score 8.05
PubMed score by year
PubTator Score 2.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title