You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CISD2
CDGSH iron-sulfur domain-containing protein 2

Protein Summary
Description
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273986
  • ENSP00000273986
  • ENSG00000145354
  • ENST00000650480
  • ENSP00000497201

Symbol
  • CDGSH2
  • ERIS
  • ZCD2
  • ERIS
  • WFS2
  • ZCD2
  • NAF-1
  • Miner1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.85
kinase perturbation
0.84
transcription factor perturbation
0.68
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.98   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.98   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999783635
p_ni:  0.000216365
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.995999715
p_ni:  0.003970752
p_wrong:  0.000029532
Data Source:  BioPlex
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.987649742
p_ni:  0.012246352
p_wrong:  0.000103906
Data Source:  BioPlex
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.985461532
p_ni:  0.014538134
p_wrong:  3.35e-7
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.978172422
p_ni:  0.021827552
p_wrong:  2.5e-8
Data Source:  BioPlex
CISD1
Tchem
Novelty:  0.0118675
p_int:  0.97337359
p_ni:  0.02662627
p_wrong:  1.39e-7
Data Source:  BioPlex
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.972205283
p_ni:  0.027794516
p_wrong:  2.01e-7
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.953373725
p_ni:  0.010167213
p_wrong:  0.036459062
Data Source:  BioPlex
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
p_int:  0.934630547
p_ni:  0.018993537
p_wrong:  0.046375916
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.925195487
p_ni:  0.071516194
p_wrong:  0.003288319
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
2
6.3
89
diastolic blood pressure
1
1
1
73.6
1
1
0
1.1
65.5
alkaline phosphatase measurement
1
1
1
64.4
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
6.3
89
diastolic blood pressure
1
73.6
0
1.1
65.5
alkaline phosphatase measurement
1
64.4
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDGSH iron sulfur domain 2
VGNC:580
100609495
Mouse
MGI:1914256
67006
Rat
RGD:1566242
295457
Dog
CDGSH iron sulfur domain 2
VGNC:39279
106558129
Horse
CDGSH iron sulfur domain 2
VGNC:16556
100630458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDGSH iron sulfur domain 2
Mouse
Rat
Dog
CDGSH iron sulfur domain 2
Horse
CDGSH iron sulfur domain 2
Publication Statistics
PubMed Score 84.98
PubMed score by year
PubTator Score 39.76
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title