CIRBP
Cold-inducible RNA-binding protein
Protein Summary
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
- ENST00000320936
- ENSP00000322887
- ENSG00000099622
- ENST00000413636
- ENSP00000412831
- ENST00000585630
- ENSP00000466110
- ENST00000586472
- ENSP00000465779
- ENST00000588030
- ENSP00000468788
- ENST00000588090
- ENSP00000466207
- A18HNRNP
- CIRP
- CIRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.97 | ||
transcription factor binding site profile | 0.93 | ||
gene perturbation | 0.86 | ||
tissue | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.4 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 319 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 338.4 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 319 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0