CIR1
Corepressor interacting with RBPJ 1
Protein Summary
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
- ENST00000342016
- ENSP00000339723
- ENSG00000138433
- CIR
- CIR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
kinase perturbation | 0.71 | ||
tissue sample | 0.63 | ||
small molecule perturbation | 0.62 | ||
cellular component | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.95 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.95 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
CCNYL1
Novelty: 0.45350824
p_int: 0.998634212
p_ni: 0.001365433
p_wrong: 3.55e-7
Data Source: BioPlex
UBR3
Family: Enzyme
Novelty: 0.14930754
p_int: 0.991181148
p_ni: 0.008818852
Data Source: BioPlex
GCA
Novelty: 0.01485875
p_int: 0.9851867
p_ni: 0.014804243
p_wrong: 0.000009058
Score: 0.253
Data Source: BioPlex,STRINGDB
BTBD1
Novelty: 0.19772296
p_int: 0.925493608
p_ni: 0.062364724
p_wrong: 0.012141669
Data Source: BioPlex
DCAF10
Novelty: 2.6713128
p_int: 0.916234344
p_ni: 0.083765656
Score: 0.159
Data Source: BioPlex,STRINGDB
CDCA3
Novelty: 0.05136899
p_int: 0.902113018
p_ni: 0.097670691
p_wrong: 0.000216291
Score: 0.189
Data Source: BioPlex,STRINGDB
RBM12
Novelty: 0.10430477
p_int: 0.849772301
p_ni: 0.14265959
p_wrong: 0.007568108
Score: 0.169
Data Source: BioPlex,STRINGDB
CTNNA2
Novelty: 0.00783865
p_int: 0.838129021
p_ni: 0.161870977
p_wrong: 2e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
EPHA2
Family: Kinase
Novelty: 0.00191002
p_int: 0.831155523
p_ni: 0.168843362
p_wrong: 0.000001114
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (5)
KEGG (2)
PathwayCommons (2)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Notch signaling pathway | ||||
KEGG | Epstein-Barr virus infection | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Notch signaling pathway | ||||
Epstein-Barr virus infection | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
grip strength measurement | 2 | 1 | 2 | 56 | |||||
body height | 1 | 1 | 1 | 45.7 | |||||
triglyceride measurement | 2 | 2 | 2 | 43.9 | |||||
physical activity measurement | 1 | 1 | 1 | 29 | |||||
HbA1c measurement | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
grip strength measurement | 2 | 56 | |||||
body height | 1 | 45.7 | |||||
triglyceride measurement | 2 | 43.9 | |||||
physical activity measurement | 1 | 29 | |||||
HbA1c measurement | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | corepressor interacting with RBPJ, 1 | VGNC:139 | 738618 | |||||
Macaque | corepressor interacting with RBPJ, 1 | 698068 | ||||||
Mouse | MGI:1914185 | 66935 | ||||||
Rat | RGD:1309199 | 362149 | ||||||
Horse | corepressor interacting with RBPJ, 1 | VGNC:16555 | 100064837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | corepressor interacting with RBPJ, 1 | |||||
Macaque | corepressor interacting with RBPJ, 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | corepressor interacting with RBPJ, 1 | |||||
Publication Statistics
PubMed Score 1.95
PubMed score by year
PubTator Score 267.18
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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