Tdark CIR1 Corepressor interacting with RBPJ 1

Protein Summary

Description

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.

Uniprot Accession IDs

• Q86X95
• A6NFI6
• A8K8M4
• O95367
• Q12804
• Q4G1B9
• Q6PJI4
• Q8IWI2

Gene Name

• CIR1

Ensembl ID

• ENST00000342016
• ENSP00000339723
• ENSG00000138433

Symbol

• CIR
• CIR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
kinase perturbation	0.71
tissue sample	0.63
small molecule perturbation	0.62
cellular component	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.35   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.35   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0