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Tbio
CIP2A
Protein CIP2A

Protein Summary
Description
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295746
  • ENSP00000295746
  • ENSG00000163507
  • ENST00000491772
  • ENSP00000419487

Symbol
  • KIAA1524
  • p90
  • KIAA1524
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.6   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.6   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.999964779
p_ni:  0.000035221
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.998213883
p_ni:  0.001786117
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.99797193
p_ni:  0.00202807
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.997842369
p_ni:  0.002157631
Data Source:  BioPlex
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.99783151
p_ni:  0.00216849
Data Source:  BioPlex
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.997561379
p_ni:  0.002438621
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.996996502
p_ni:  0.003003498
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.994496652
p_ni:  0.005503348
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.994148181
p_ni:  0.005851819
Data Source:  BioPlex
LRRC61
Tdark
Novelty:  1.45343096
p_int:  0.994077115
p_ni:  0.005922885
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
49.5
self reported educational attainment
1
1
1
35
Thyroid preparation use measurement
1
1
1
29
intelligence
1
1
1
27.3
reticulocyte measurement
2
1
2
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
49.5
self reported educational attainment
1
35
Thyroid preparation use measurement
1
29
intelligence
1
27.3
reticulocyte measurement
2
12.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell proliferation regulating inhibitor of protein phosphatase 2A
VGNC:6350
741836
Macaque
cell proliferation regulating inhibitor of protein phosphatase 2A
705690
Mouse
MGI:2146335
224171
Rat
RGD:1310335
360711
Dog
cell proliferation regulating inhibitor of protein phosphatase 2A
VGNC:39277
478554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell proliferation regulating inhibitor of protein phosphatase 2A
Macaque
cell proliferation regulating inhibitor of protein phosphatase 2A
Mouse
Rat
Dog
cell proliferation regulating inhibitor of protein phosphatase 2A
Publication Statistics
PubMed Score 177.60
PubMed score by year
PubTator Score 280.10
PubTator score by year
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Related Publications
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PMID
Year
Title