Protein Summary
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
- ENST00000295746
- ENSP00000295746
- ENSG00000163507
- ENST00000491772
- ENSP00000419487
- KIAA1524
- p90
- KIAA1524
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.6 (req: < 5)
Gene RIFs: 104 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.6 (req: >= 5)
Gene RIFs: 104 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (125)
CA14
Family: Enzyme
Novelty: 0.00864764
p_int: 0.999964779
p_ni: 0.000035221
Data Source: BioPlex
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.998213883
p_ni: 0.001786117
Data Source: BioPlex
ALDH3A2
Family: Enzyme
Novelty: 0.0059198
p_int: 0.99783151
p_ni: 0.00216849
Data Source: BioPlex
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.994148181
p_ni: 0.005851819
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 2 | 1 | 2 | 49.5 | |||||
self reported educational attainment | 1 | 1 | 1 | 35 | |||||
Thyroid preparation use measurement | 1 | 1 | 1 | 29 | |||||
intelligence | 1 | 1 | 1 | 27.3 | |||||
reticulocyte measurement | 2 | 1 | 2 | 12.3 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 2 | 49.5 | |||||
self reported educational attainment | 1 | 35 | |||||
Thyroid preparation use measurement | 1 | 29 | |||||
intelligence | 1 | 27.3 | |||||
reticulocyte measurement | 2 | 12.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cell proliferation regulating inhibitor of protein phosphatase 2A | VGNC:6350 | 741836 | |||||
Macaque | cell proliferation regulating inhibitor of protein phosphatase 2A | 705690 | ||||||
Mouse | MGI:2146335 | 224171 | ||||||
Rat | RGD:1310335 | 360711 | ||||||
Dog | cell proliferation regulating inhibitor of protein phosphatase 2A | VGNC:39277 | 478554 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cell proliferation regulating inhibitor of protein phosphatase 2A | |||||
Macaque | cell proliferation regulating inhibitor of protein phosphatase 2A | |||||
Mouse | ||||||
Rat | ||||||
Dog | cell proliferation regulating inhibitor of protein phosphatase 2A | |||||
Publication Statistics
PubMed Score 177.60
PubMed score by year
PubTator Score 280.10
PubTator score by year
Related Publications
Text Mined References (115)
GeneRif Annotations (104)
Items per page:
0 of 0
PMID | Year | Title |
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