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Tbio
CILP2
Cartilage intermediate layer protein 2

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.999991892
p_ni:  0.000008086
p_wrong:  2.2e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.999988924
p_ni:  3.53e-7
p_wrong:  0.000010723
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.999976045
p_ni:  0.000023925
p_wrong:  2.9e-8
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.992946264
p_ni:  0.006910417
p_wrong:  0.000143319
Data Source:  BioPlex
TM6SF2
Tbio
Novelty:  0.00965899
Score:  0.83
Data Source:  STRINGDB
PBX4
Tbio
Family:  TF
Novelty:  0.09471693
Score:  0.792
Data Source:  STRINGDB
LYPLAL1
Tbio
Family:  Enzyme
Novelty:  0.0447394
Score:  0.68
Data Source:  STRINGDB
TRIB1
Tbio
Family:  Kinase
Novelty:  0.01587891
Score:  0.669
Data Source:  STRINGDB
GALNT2
Tchem
Family:  Enzyme
Novelty:  0.02458542
Score:  0.649
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
4
7
6.9
97.7
red blood cell distribution width
3
3
3
93.3
platelet crit
2
2
3
90.3
total cholesterol measurement
2
2
2
90
low density lipoprotein cholesterol measurement
3
2
2
3.3
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
6.9
97.7
red blood cell distribution width
3
93.3
platelet crit
3
90.3
total cholesterol measurement
2
90
low density lipoprotein cholesterol measurement
2
3.3
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cartilage intermediate layer protein 2
VGNC:3642
107969843
Macaque
cartilage intermediate layer protein 2
716547
Mouse
MGI:1915959
68709
Rat
RGD:1311157
306356
Dog
cartilage intermediate layer protein 2
VGNC:39275
484804
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cartilage intermediate layer protein 2
Macaque
cartilage intermediate layer protein 2
Mouse
Rat
Dog
cartilage intermediate layer protein 2
Publication Statistics
PubMed Score 13.92
PubMed score by year
PubTator Score 9.73
PubTator score by year
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Related Publications
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PMID
Year
Title