You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CIB1
Calcium and integrin-binding protein 1

Protein Summary
Description
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328649
  • ENSP00000333873
  • ENSG00000185043
  • ENST00000612800
  • ENSP00000479860

Symbol
  • CIB
  • KIP
  • PRKDCIP
  • CIB
  • CIBP
  • KIP1
  • PRKDCIP
  • SIP2-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.9
kinase perturbation
0.81
cellular component
0.8
molecular function
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.13   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.13   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0