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Tbio
CIART
Circadian-associated transcriptional repressor

Protein Summary
Description
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290363
  • ENSP00000290363
  • ENSG00000159208
  • ENST00000369095
  • ENSP00000358091

Symbol
  • C1orf51
  • GM129
  • CHRONO
  • C1orf51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
histone modification site profile
0.72
tissue sample
0.68
cell type or tissue
0.6
biological process
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
IGHA2
Tbio
p_int:  0.996893407
p_ni:  0.003080158
p_wrong:  0.000026435
Data Source:  BioPlex
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.989012036
p_ni:  0.010987964
Score:  0.28
Data Source:  BioPlex,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
p_int:  0.933361519
p_ni:  0.066638481
Score:  0.345
Data Source:  BioPlex,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.786
Data Source:  STRINGDB
CRY2
Tbio
Novelty:  0.00156961
Score:  0.765
Data Source:  STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
Score:  0.7
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.675
Data Source:  STRINGDB
GP6
Tbio
Novelty:  0.0010722
Score:  0.669
Data Source:  STRINGDB
SELP
Tclin
Novelty:  0.00019779
Score:  0.648
Data Source:  STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.611
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
5
3
1
94.2
glomerular filtration rate
4
4
4
87.4
circadian rhythm
5
3
3
1.1
83.6
red blood cell distribution width
2
2
2
68.8
platelet count
2
2
2
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1
94.2
glomerular filtration rate
4
87.4
circadian rhythm
3
1.1
83.6
red blood cell distribution width
2
68.8
platelet count
2
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
circadian associated repressor of transcription
VGNC:499
457271
Mouse
MGI:2684975
229599
Rat
RGD:1566380
365871
Dog
circadian associated repressor of transcription
VGNC:39265
100856543
Horse
circadian associated repressor of transcription
VGNC:16544
100058902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
circadian associated repressor of transcription
Mouse
Rat
Dog
circadian associated repressor of transcription
Horse
circadian associated repressor of transcription
Publication Statistics
PubMed Score 10.49
PubMed score by year
PubTator Score 2.29
PubTator score by year
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Related Publications
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PMID
Year
Title