Protein Summary
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or ...more
- ENST00000394391
- ENSP00000377914
- ENSG00000005194
- ENST00000567518
- ENSP00000456114
- DRE2
- CIAE2
- PRO0915
- Anamorsin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
histone modification site profile | 0.91 | ||
transcription factor perturbation | 0.8 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.92 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 332 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.92 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 332 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (111)
GLRX3
Novelty: 0.0096265
p_int: 0.999997386
p_ni: 0.000002614
Score: 0.995
Data Source: BioPlex,STRINGDB
CACNB3
Family: IC
Novelty: 0.04007679
p_int: 0.999981471
p_ni: 0.000018529
Score: 0.323
Data Source: BioPlex,STRINGDB
NDOR1
Family: Enzyme
Novelty: 0.07400532
p_int: 0.999964066
p_ni: 0.000035932
p_wrong: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
BOLA1
Novelty: 0.1092583
p_int: 0.997856869
p_ni: 0.002143131
Score: 0.962
Data Source: BioPlex,STRINGDB
RGS20
Novelty: 0.04087618
p_int: 0.822335654
p_ni: 0.177664346
Score: 0.647
Data Source: BioPlex,STRINGDB
BBOX1
Family: Enzyme
Novelty: 0.00255489
p_int: 0.772627471
p_ni: 0.227372527
p_wrong: 2e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic iron-sulfur cluster assembly | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic iron-sulfur cluster assembly | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-UniRule | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
CX3CL1 measurement | 1 | 1 | 1 | 86.9 | |||||
CCL17 measurement | 1 | 1 | 1 | 79.4 | |||||
blood protein measurement | 1 | 1 | 1 | 76.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 64 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 58.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
CX3CL1 measurement | 1 | 86.9 | |||||
CCL17 measurement | 1 | 79.4 | |||||
blood protein measurement | 1 | 76.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 64 | |||||
apolipoprotein A 1 measurement | 2 | 58.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytokine induced apoptosis inhibitor 1 | VGNC:5736 | 454117 | |||||
Macaque | cytokine induced apoptosis inhibitor 1 | 704770 | ||||||
Mouse | MGI:1922083 | 109006 | ||||||
Rat | RGD:1549737 | 307649 | ||||||
Dog | cytokine induced apoptosis inhibitor 1 | VGNC:39264 | 478111 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytokine induced apoptosis inhibitor 1 | |||||
Macaque | cytokine induced apoptosis inhibitor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytokine induced apoptosis inhibitor 1 | |||||
Publication Statistics
PubMed Score 94.92
PubMed score by year
PubTator Score 36.77
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
---|