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Tbio
CIAPIN1
Anamorsin

Protein Summary
Description
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394391
  • ENSP00000377914
  • ENSG00000005194
  • ENST00000567518
  • ENSP00000456114

Symbol
  • DRE2
  • CIAE2
  • PRO0915
  • Anamorsin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
histone modification site profile
0.91
transcription factor perturbation
0.8
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
GLRX3
Tbio
Novelty:  0.0096265
p_int:  0.999997386
p_ni:  0.000002614
Score:  0.995
Data Source:  BioPlex,STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
p_int:  0.999981471
p_ni:  0.000018529
Score:  0.323
Data Source:  BioPlex,STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
p_int:  0.999964066
p_ni:  0.000035932
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
p_int:  0.997856869
p_ni:  0.002143131
Score:  0.962
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.822335654
p_ni:  0.177664346
Score:  0.647
Data Source:  BioPlex,STRINGDB
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
p_int:  0.772627471
p_ni:  0.227372527
p_wrong:  2e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.992
Data Source:  STRINGDB
NUBP2
Tbio
Novelty:  0.01136095
Score:  0.983
Data Source:  STRINGDB
POLD1
Tclin
Family:  Enzyme
Novelty:  0.00508209
Score:  0.945
Data Source:  STRINGDB
RTEL1
Tbio
Family:  Enzyme
Novelty:  0.00761538
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
1
1
86.9
CCL17 measurement
1
1
1
79.4
blood protein measurement
1
1
1
76.7
high density lipoprotein cholesterol measurement
1
1
1
64
apolipoprotein A 1 measurement
2
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
86.9
CCL17 measurement
1
79.4
blood protein measurement
1
76.7
high density lipoprotein cholesterol measurement
1
64
apolipoprotein A 1 measurement
2
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytokine induced apoptosis inhibitor 1
VGNC:5736
454117
Macaque
cytokine induced apoptosis inhibitor 1
704770
Mouse
MGI:1922083
109006
Rat
RGD:1549737
307649
Dog
cytokine induced apoptosis inhibitor 1
VGNC:39264
478111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytokine induced apoptosis inhibitor 1
Macaque
cytokine induced apoptosis inhibitor 1
Mouse
Rat
Dog
cytokine induced apoptosis inhibitor 1
Publication Statistics
PubMed Score 94.92
PubMed score by year
PubTator Score 36.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title