Tbio CIAPIN1 Anamorsin

Protein Summary

Description

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6FI81
• A8K8B6
• O75206
• O75207
• Q9H0W1
• Q9P1L7

Gene Name

• CIAPIN1

Ensembl ID

• ENST00000394391
• ENSP00000377914
• ENSG00000005194
• ENST00000567518
• ENSP00000456114

Symbol

• DRE2
• CIAE2
• PRO0915
• Anamorsin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.93
histone modification site profile	0.91
transcription factor perturbation	0.8
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

GLRX3

Tbio

Novelty:  0.0096265

p_int:  0.999997386

p_ni:  0.000002614

Score:  0.995

Data Source:  BioPlex,STRINGDB

CACNB3

Tbio

Family:  IC

Novelty:  0.04007679

p_int:  0.999981471

p_ni:  0.000018529

Score:  0.323

Data Source:  BioPlex,STRINGDB

NDOR1

Tbio

Family:  Enzyme

Novelty:  0.07400532

p_int:  0.999964066

p_ni:  0.000035932

p_wrong:  3e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

BOLA1

Tbio

Novelty:  0.1092583

p_int:  0.997856869

p_ni:  0.002143131

Score:  0.962

Data Source:  BioPlex,STRINGDB

RGS20

Tbio

Novelty:  0.04087618

p_int:  0.822335654

p_ni:  0.177664346

Score:  0.647

Data Source:  BioPlex,STRINGDB

BBOX1

Tchem

Family:  Enzyme

Novelty:  0.00255489

p_int:  0.772627471

p_ni:  0.227372527

p_wrong:  2e-9

Score:  0.201

Data Source:  BioPlex,STRINGDB

NUBP1

Tbio

Novelty:  0.03429412

Score:  0.992

Data Source:  STRINGDB

NUBP2

Tbio

Novelty:  0.01136095

Score:  0.983

Data Source:  STRINGDB

POLD1

Tclin

Family:  Enzyme

Novelty:  0.00508209

Score:  0.945

Data Source:  STRINGDB

RTEL1

Tbio

Family:  Enzyme

Novelty:  0.00761538

Score:  0.928

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic iron-sulfur cluster assembly	13 targets	R-HSA-2564830
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Cytosolic iron-sulfur cluster assembly	13 targets	R-HSA-2564830
Metabolism	2112 targets	R-HSA-1430728

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (5)

Components (5)

Processes (4)

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1 – 5 of 5

GO Term	Evidence	Assigned by
2 iron, 2 sulfur cluster binding	Inferred from Direct Assay (IDA)	UniProtKB
4 iron, 4 sulfur cluster binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
electron transfer activity	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
methyltransferase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
CX3CL1 measurement	EFO_0009419	1	1	1		86.9
CCL17 measurement	EFO_0009414	1	1	1		79.4
blood protein measurement	EFO_0007937	1	1	1		76.7
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		64
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		58.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
CX3CL1 measurement	EFO_0009419	1		86.9
CCL17 measurement	EFO_0009414	1		79.4
blood protein measurement	EFO_0007937	1		76.7
high density lipoprotein cholesterol measurement	EFO_0004612	1		64
apolipoprotein A 1 measurement	EFO_0004614	2		58.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
2Fe-2S
3D-structure
4Fe-4S
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Iron
Iron-sulfur
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
basophil count
blood protein measurement
CCL17 measurement
CX3CL1 measurement
eosinophil count
eosinophil percentage of leukocytes
high density lipoprotein cholesterol measurement
mean corpuscular hemoglobin concentration
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytokine induced apoptosis inhibitor 1	VGNC:5736	454117
Macaque	cytokine induced apoptosis inhibitor 1		704770
Mouse	cytokine induced apoptosis inhibitor 1	MGI:1922083	109006
Rat	cytokine induced apoptosis inhibitor 1	RGD:1549737	307649
Dog	cytokine induced apoptosis inhibitor 1	VGNC:39264	478111

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytokine induced apoptosis inhibitor 1
Macaque	cytokine induced apoptosis inhibitor 1
Mouse	cytokine induced apoptosis inhibitor 1
Rat	cytokine induced apoptosis inhibitor 1
Dog	cytokine induced apoptosis inhibitor 1

Publication Statistics

PubMed Score 94.92

PubMed score by year

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PubTator Score 36.77

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (27)

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PMID	Year	Title