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Tbio
CIAO3
Cytosolic iron-sulfur assembly component 3

Protein Summary
Description
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251588
  • ENSP00000251588
  • ENSG00000103245
  • ENST00000540986
  • ENSP00000444008
  • ENST00000568545
  • ENSP00000457058

Symbol
  • NARFL
  • PRN
  • PRN
  • HPRN
  • IOP1
  • NAR1
  • LET1L
  • NARFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor
0.79
transcription factor binding site profile
0.77
tissue sample
0.7
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.18   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.18   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0