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Tbio
CIAO3
Cytosolic iron-sulfur assembly component 3

Protein Summary
Description
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251588
  • ENSP00000251588
  • ENSG00000103245
  • ENST00000540986
  • ENSP00000444008
  • ENST00000568545
  • ENSP00000457058

Symbol
  • NARFL
  • PRN
  • PRN
  • HPRN
  • IOP1
  • NAR1
  • LET1L
  • NARFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor
0.79
transcription factor binding site profile
0.77
tissue sample
0.7
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ZBTB39
Tdark
Novelty:  3.35049002
p_int:  0.999998995
p_ni:  0.000001005
Score:  0.269
Data Source:  BioPlex,STRINGDB
CIAO2A
Tbio
Novelty:  0.16823665
p_int:  0.999965163
p_ni:  0.000023136
p_wrong:  0.000011701
Score:  0.749
Data Source:  BioPlex,STRINGDB
DTX3
Tbio
Family:  Enzyme
Novelty:  0.06212096
p_int:  0.999786258
p_ni:  0.000195235
p_wrong:  0.000018507
Score:  0.516
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999641922
p_ni:  0.000157799
p_wrong:  0.000200279
Data Source:  BioPlex
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.997760218
p_ni:  0.002239782
Score:  0.187
Data Source:  BioPlex,STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.98771929
p_ni:  0.0122807
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.86710446
p_ni:  0.132895523
p_wrong:  1.7e-8
Score:  0.171
Data Source:  BioPlex,STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.997
Data Source:  STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
Score:  0.992
Data Source:  Reactome,STRINGDB
MMS19
Tbio
Novelty:  0.01978769
Score:  0.989
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 166.76
PubMed score by year
PubTator Score 108.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title