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Tbio
CIAO2B
Cytosolic iron-sulfur assembly component 2B

Protein Summary
Description
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422424
  • ENSP00000387471
  • ENSG00000166595

Symbol
  • CIAB
  • FAM96B
  • MIP18
  • CIA2B
  • MIP18
  • FAM96B
  • CGI-128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
disease perturbation
0.79
tissue sample
0.7
transcription factor binding site profile
0.7
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
MMS19
Tbio
Novelty:  0.01978769
p_int:  0.867618591
p_ni:  0.132381409
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
p_int:  0.794027747
p_ni:  0.205972186
p_wrong:  6.7e-8
Score:  0.848
Data Source:  BioPlex,STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
Score:  0.999
Data Source:  Reactome,STRINGDB
CIAO3
Tbio
Novelty:  0.00627147
Score:  0.986
Data Source:  Reactome,STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.976
Data Source:  STRINGDB
NUBP2
Tbio
Novelty:  0.01136095
Score:  0.967
Data Source:  STRINGDB
RTEL1
Tbio
Family:  Enzyme
Novelty:  0.00761538
Score:  0.958
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.956
Data Source:  STRINGDB
SLC25A5
Tchem
Family:  Transporter
Novelty:  0.00749909
Score:  0.947
Data Source:  STRINGDB
POLD1
Tclin
Family:  Enzyme
Novelty:  0.00508209
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
4
4
87.9
high density lipoprotein cholesterol measurement
2
3
4
83.3
heel bone mineral density
2
2
2
80.6
diastolic blood pressure
1
1
1
73.7
blood protein measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
4
87.9
high density lipoprotein cholesterol measurement
4
83.3
heel bone mineral density
2
80.6
diastolic blood pressure
1
73.7
blood protein measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 8.28
PubMed score by year
PubTator Score 7.58
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title