Tbio CHURC1 Protein Churchill

Protein Summary

Description

Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.

Uniprot Accession IDs

• Q8WUH1
• B3KQ81
• G3V1X3
• G3V214
• Q9H3K7

Gene Name

• CHURC1

Ensembl ID

• ENST00000548752
• ENSP00000450165
• ENSG00000258289
• ENST00000549115
• ENSP00000448050
• ENST00000607599
• ENSP00000475473

Symbol

• C14orf52
• CHCH
• chch
• My015
• C14orf52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.78
histone modification site profile	0.73
microRNA	0.66
tissue sample	0.63
small molecule perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

• See Interactions on String-DB

NMT2

Tchem

Family:  Enzyme

Novelty:  0.04826835

p_int:  0.999998282

p_ni:  0.000001718

Data Source:  BioPlex

NMT1

Tchem

Family:  Enzyme

Novelty:  0.00343834

p_int:  0.999420116

p_ni:  0.000579884

Data Source:  BioPlex

ACTR3B

Tbio

Novelty:  0.06033214

p_int:  0.998993393

p_ni:  6.3e-8

p_wrong:  0.001006544

Score:  0.286

Data Source:  BioPlex,STRINGDB

UBB

Tbio

Novelty:  0.00661254

p_int:  0.997574715

p_ni:  0.002424848

p_wrong:  4.37e-7

Data Source:  BioPlex

MTMR14

Tbio

Family:  Enzyme

Novelty:  0.07074944

p_int:  0.996234934

p_ni:  0.003765064

p_wrong:  1e-9

Data Source:  BioPlex

ACTR2

Tchem

Novelty:  0.00731489

p_int:  0.975948134

p_ni:  0.024051866

Data Source:  BioPlex

CREBBP

Tchem

Family:  Epigenetic

Novelty:  0.00111166

p_int:  0.765868302

p_ni:  0.233687647

p_wrong:  0.000444051

Data Source:  BioPlex

GLRX

Tbio

Novelty:  0.00111903

p_int:  0.757488791

p_ni:  0.008064526

p_wrong:  0.234446684

Data Source:  BioPlex

PLAG1

Tbio

Family:  TF

Novelty:  0.00665136

Score:  0.8

Data Source:  STRINGDB

PPIL6

Tdark

Family:  Enzyme

Novelty:  1.46776073

Score:  0.721

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Processes (2)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2	6	6		97.3
reticulocyte count	EFO_0007986	2	3	4		96.4
reticulocyte measurement	EFO_0010700	3	3	5		96.4
mean reticulocyte volume	EFO_0010701	1	4	4		94.5
red blood cell distribution width	EFO_0005192	2	2	2		89.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	6		97.3
reticulocyte count	EFO_0007986	4		96.4
reticulocyte measurement	EFO_0010700	5		96.4
mean reticulocyte volume	EFO_0010701	4		94.5
red blood cell distribution width	EFO_0005192	2		89.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Activator
Alternative splicing
Complete proteome
Developmental protein
Metal-binding
Reference proteome
Transcription
Transcription regulation
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
bilirubin measurement
erythrocyte count
erythrocyte measurement
HbA1c measurement
hemoglobin measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume
mean reticulocyte volume
platelet count

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	churchill domain containing 1	MGI:1923684	211151
Rat	churchill domain containing 1	RGD:1305116	299154
Dog	churchill domain containing 1	VGNC:39262	609942
Horse	churchill domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20099]
Cow	churchill domain containing 1	VGNC:27355	616539

Species	Name	OMA	EggNOG	Inparanoid
Mouse	churchill domain containing 1
Rat	churchill domain containing 1
Dog	churchill domain containing 1
Horse	churchill domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20099]
Cow	churchill domain containing 1

Publication Statistics

PubMed Score 21.25

PubMed score by year

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PubTator Score 102.02

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title