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Tchem
CHUK
Inhibitor of nuclear factor kappa-B kinase subunit alpha

Protein Summary
Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370397
  • ENSP00000359424
  • ENSG00000213341

Symbol
  • IKKA
  • TCF16
  • IKK1
  • IKKA
  • IKBKA
  • TCF16
  • NFKBIKA
  • IKK-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.99
pathway
0.99
biological term
0.98
chemical
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.1   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 1368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.1   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 1368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0