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Tbio
CHTOP
Chromatin target of PRMT1 protein

Protein Summary
Description
Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368690
  • ENSP00000357679
  • ENSG00000160679
  • ENST00000368694
  • ENSP00000357683
  • ENST00000403433
  • ENSP00000385228

Symbol
  • C1orf77
  • FOP
  • FOP
  • SRAG
  • SRAG-3
  • SRAG-5
  • pp7704
  • C1orf77
  • FL-SRAG
  • C10orf77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
interacting protein
0.85
co-expressed gene
0.79
disease
0.68
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.84   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.84   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
CIZ1
Tbio
Novelty:  0.03730538
p_int:  0.999996246
p_ni:  0.000003754
Data Source:  BioPlex
ERH
Tbio
Novelty:  0.00711649
p_int:  0.999929512
p_ni:  0.000070488
Score:  0.948
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.999724266
p_ni:  0.000085927
p_wrong:  0.000189807
Data Source:  BioPlex
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.999033035
p_ni:  0.000966949
p_wrong:  1.6e-8
Data Source:  BioPlex
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.998416163
p_ni:  0.001583837
Data Source:  BioPlex
NCBP3
Tbio
Novelty:  0.07581882
p_int:  0.998166937
p_ni:  0.001833063
Score:  0.598
Data Source:  BioPlex,STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
p_int:  0.997889087
p_ni:  0.002110913
Score:  0.707
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.997743719
p_ni:  0.002256281
Data Source:  BioPlex
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.997608172
p_ni:  0.002391828
Score:  0.281
Data Source:  BioPlex,STRINGDB
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.997592218
p_ni:  0.002407782
Score:  0.984
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
monocyte count
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
monocyte count
1
9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromatin target of PRMT1
VGNC:498
738288
Macaque
chromatin target of PRMT1
715501
Mouse
MGI:1913761
66511
Rat
RGD:1359407
361990
Dog
chromatin target of PRMT1
VGNC:53336
480140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromatin target of PRMT1
Macaque
chromatin target of PRMT1
Mouse
Rat
Dog
chromatin target of PRMT1
Publication Statistics
PubMed Score 28.84
PubMed score by year
PubTator Score 11.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title