Tbio CHSY3 Chondroitin sulfate synthase 3

Protein Summary

Description

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q70JA7
• B2RP97
• Q76L22
• Q86Y52

Gene Name

• CHSY3

Ensembl ID

• ENST00000305031
• ENSP00000302629
• ENSG00000198108

Symbol

• CHSY2
• CSS3
• CSS3
• CHSY2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.92
histone modification site profile	0.73
phenotype	0.72
gene perturbation	0.65
cellular component	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 3

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0