Tbio CHST8 Carbohydrate sulfotransferase 8

Protein Summary

Description

Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9H2A9
• Q9H3N2

Gene Name

• CHST8

Ensembl ID

• ENST00000262622
• ENSP00000262622
• ENSG00000124302
• ENST00000434302
• ENSP00000392604
• ENST00000438847
• ENSP00000393879

Symbol

• PSS3
• GalNAc4ST
• GALNAC4ST1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.69
transcription factor	0.64
cell line	0.63
small molecule perturbation	0.63
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Transferase / Carbohydrate Sulfotransferase 8

DTO Classes

Protein / Enzyme / Transferase / Carbohydrate Sulfotransferase 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.97   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.97   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0