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Tbio
CHST8
Carbohydrate sulfotransferase 8

Protein Summary
Description
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262622
  • ENSP00000262622
  • ENSG00000124302
  • ENST00000434302
  • ENSP00000392604
  • ENST00000438847
  • ENSP00000393879

Symbol
  • PSS3
  • GalNAc4ST
  • GALNAC4ST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.69
transcription factor
0.64
cell line
0.63
small molecule perturbation
0.63
tissue sample
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.99   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.99   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
GAL3ST1
Tbio
Family:  Enzyme
Novelty:  0.02939055
p_int:  0.999999215
p_ni:  7.84e-7
p_wrong:  1e-9
Score:  0.382
Data Source:  BioPlex,STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999765302
p_ni:  0.000234697
p_wrong:  1e-9
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.999179807
p_ni:  0.000820193
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.998558294
p_ni:  0.001441706
Data Source:  BioPlex
B3GALNT2
Tbio
Family:  Enzyme
Novelty:  0.08266178
p_int:  0.997527901
p_ni:  0.002472099
Score:  0.194
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.997443771
p_ni:  0.002556229
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.996013318
p_ni:  0.000002367
p_wrong:  0.003984315
Score:  0.209
Data Source:  BioPlex,STRINGDB
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
p_int:  0.994429868
p_ni:  0.005570132
Data Source:  BioPlex
RRP1
Tbio
Novelty:  0.12984245
p_int:  0.992333342
p_ni:  0.007666657
Data Source:  BioPlex
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.987416855
p_ni:  0.012583145
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Reactome
Reactions specific to the complex N-glycan synthesis pathway
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Reactions specific to the complex N-glycan synthesis pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
13
7
15
4.2
90.7
waist-hip ratio
1
2
2
50.6
BMI-adjusted waist-hip ratio
1
2
2
49.4
physical activity measurement
1
2
2
44.1
facial morphology measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4.2
90.7
waist-hip ratio
2
50.6
BMI-adjusted waist-hip ratio
2
49.4
physical activity measurement
2
44.1
facial morphology measurement
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 8
VGNC:10160
468819
Macaque
carbohydrate sulfotransferase 8 [Source:HGNC Symbol;Acc:HGNC:15993]
Mouse
MGI:1916197
68947
Rat
RGD:1308979
308511
Dog
carbohydrate sulfotransferase 8
VGNC:39258
484596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 8
Macaque
carbohydrate sulfotransferase 8 [Source:HGNC Symbol;Acc:HGNC:15993]
Mouse
Rat
Dog
carbohydrate sulfotransferase 8
Publication Statistics
PubMed Score 28.99
PubMed score by year
PubTator Score 20.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title