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Tbio
CHST6
Carbohydrate sulfotransferase 6

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332272
  • ENSP00000328983
  • ENSG00000183196
  • ENST00000390664
  • ENSP00000375079
  • ENST00000649341
  • ENSP00000497635
  • ENST00000649824
  • ENSP00000496806
  • ENST00000650254
  • ENSP00000497758

Symbol
  • MCDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
histone modification site profile
0.62
cellular component
0.6
pathway
0.58
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.58   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.58   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
CHST4
Tbio
Family:  Enzyme
Novelty:  0.02345662
p_int:  0.999838688
p_wrong:  0.000161312
Score:  0.41
Data Source:  BioPlex,STRINGDB
LRRC3
Tdark
Novelty:  0.13484671
p_int:  0.999733075
p_ni:  0.000266925
Data Source:  BioPlex
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.99898015
p_ni:  0.000936183
p_wrong:  0.000083667
Score:  0.537
Data Source:  BioPlex,STRINGDB
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.99396417
p_ni:  0.006034581
p_wrong:  0.000001249
Data Source:  BioPlex
GLB1L2
Tdark
Family:  Enzyme
Novelty:  1.03866932
p_int:  0.989633071
p_ni:  0.010366929
Score:  0.218
Data Source:  BioPlex,STRINGDB
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.984863453
p_ni:  0.010433398
p_wrong:  0.004703149
Score:  0.183
Data Source:  BioPlex,STRINGDB
BACE2
Tchem
Family:  Enzyme
Novelty:  0.00559862
p_int:  0.982152998
p_ni:  0.017759462
p_wrong:  0.00008754
Score:  0.179
Data Source:  BioPlex,STRINGDB
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.977955284
p_ni:  0.022044296
p_wrong:  4.19e-7
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.977266771
p_ni:  0.022733229
Data Source:  BioPlex
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.974174585
p_ni:  0.025675152
p_wrong:  0.000150263
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Defective CHST6 causes MCDC1 (R-HSA-3656225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CHST6 causes MCDC1
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Reactome
Diseases of glycosylation
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective CHST6 causes MCDC1
Disease
Diseases associated with glycosaminoglycan metabolism
Diseases of glycosylation
Glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
3
88.6
FEV/FEC ratio
1
1
1
84.9
peak expiratory flow
1
1
1
80.5
platelet crit
1
1
1
74.4
forced expiratory volume
1
1
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
88.6
FEV/FEC ratio
1
84.9
peak expiratory flow
1
80.5
platelet crit
1
74.4
forced expiratory volume
1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 6 [Source:HGNC Symbol;Acc:HGNC:6938]
Macaque
carbohydrate sulfotransferase 6
711570
Mouse
MGI:1931825
56773
Rat
RGD:1561144
307859
Horse
carbohydrate sulfotransferase 6
100068994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 6 [Source:HGNC Symbol;Acc:HGNC:6938]
Macaque
carbohydrate sulfotransferase 6
Mouse
Rat
Horse
carbohydrate sulfotransferase 6
Publication Statistics
PubMed Score 57.58
PubMed score by year
PubTator Score 46.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title